| Project/Area Number |
26660228
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Gifu University |
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Principal Investigator |
FUKUSHI Hideto 岐阜大学, 応用生物科学部, 教授 (10156763)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ヘルペスウイルス / ロングノンコーディングRNA / 遺伝子発現調節 / long non-coding RNA / ウマヘルペスウイルス1型 / ウマヘルペスウイルス１型 |
|---|
| Outline of Final Research Achievements |
Virus genes are efficiently arranged on the genome. However, the herpesvirus genomes have long non-coding regions on their genomes. The purpose of the present study is to reveal functions of the long non-coding regions in viral replication using equine herpesvirus 1 (EHV-1) as a model virus. Two long non-coding RNA, 1028 bps (lncRNA-X1) and 679 bps (lncRNA-X2), were found as transcripts. It was found that several gene expressions were under detection limits in murine cultivated neuronal cell infected by a mutant EHV-1 lacking lncRNA-X1 and lncRNA-X2. The results indicated that the lncRNAs might have roles for EHV-1 replication in neuronal cells.
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