| Project/Area Number |
26660230
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Veterinary medical science
|
|---|
| Research Institution | Osaka Prefecture University |
|---|
Principal Investigator |
Azuma Yasu-Taka 大阪府立大学, 生命環境科学研究科(系), 准教授 (50298816)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KURAMOTO NOBUYUKI 摂南大学, 薬学部, 准教授 (60324092)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | トランスポーター / 免疫系 / カルシウム / サイトカイン |
|---|
| Outline of Final Research Achievements |
In order to demonstrate roles of Na+/Ca2+ exchanger（NCX）on macrophages function, we determined whether NCX deficiency affects the cytokine production in bone marrow-derived macrophages response to LPS in vitro. Macrophages from NCX1 heterozygote mice, NCX2 heterozygote mice and NCX3 homozygote mice produced similar levels of pro-inflammatory cytokines in macrophages from wild-type.
|
