The development of a novel sensitizing radiation therapy in conjunction with microbubbles and ultrasound exposure
| Project/Area Number |
26660233
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Noboru 北海道大学, 大学院獣医学研究科, 助教 (00754532)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 獣医学 / 超音波 / マイクロバブル / 増感放射線療法 / ソノポレーション |
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| Outline of Final Research Achievements |
The purpose of this study is to clarify the sensitizing effect of irradiation-induced apoptosis after ultrasound exposure in the presence of microbubbles. Mouse sequemous cell carcinoma cell was irradiated right after the ultrasonic exposure with microbubbles resulted in sensitizing effect of 1.1. After considering optimal irradiation timing in the light of the effect of cell cycle variation of ultrasound exposure, it was suggested that 9 hours after the ultrasound exposure was suitable. However, the sensitizing effect of irradiation-induced apoptosis remained 1.1. Further study is needed using 3-dimensional cell culture system.
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Report
(3 results)
Research Products
(1 results)
