| Project/Area Number |
26660238
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHII Naohito 岐阜大学, 応用生物科学部, 准教授 (20508478)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 抗インスリンIgG / ネコ / 結合親和性 / インスリン / グルコース |
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| Outline of Final Research Achievements |
All healthy adult cats had plasma anti-insulin IgG concentrations between 80-1578 mcg/ml. Anti-insulin IgGs were fractionated into 2 fractions; 1 and 2, and their affinities for insulin were moderate degree. The affinitas was most strong with the carboxyl terminal and secondary with 6-15 amino-acid residues of insulin B chain, suggesting binding inhibition of insulin and it’s receptors and forming of macromolecule complex. Fraction 1 made to increase phosphorylated Akt and uptake of glucose by matured cat adipose cells. Cats have a anti-insulin IgG with increases in insulin action.
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