| Project/Area Number |
26660241
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 養育放棄 / 母性行動異常 / 食殺行動 / アトピー性皮膚炎 / NC/Tndマウス / うつ病 / 育児放棄 / ストレス / 疾患モデル |
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| Outline of Final Research Achievements |
The NC/Tnd mouse, which is formerly known as NC/NgaTnd, is a spontaneous model of human atopic dermatitis. NC/Tnd mothers tend to neglect her pups and to display infanticide caused by slight environmental changes. We found that the number of NC/Tnd mothers display infanticide significantly increase in winter. Thus, we hypothesized that the infanticidal behavior of NC/Tnd mothers is induced by slight low temperature environment.
In slight low temperature environment, the infanticidal rate of NC/Tnd mothers significantly increased, whereas that of BALB/c mothers, which are control mice, did not. On the other hand, the maternal behavior of NC/Tnd mothers did not display infanticide was active and excellent. However, the NC/Tnd pups showed marked inadequate growth and significant decreased survival despite being raised with adequate maternal care by their mothers.There is possibility that NC/Tnd mice are useful as a new model to clarify the mechanism of abnormality in maternal behavior.
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