Identification of genetic diseases of aged companion animals
| Project/Area Number |
26660242
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Kagoshima University |
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Principal Investigator |
Yamato Osamu 鹿児島大学, 農水産獣医学域獣医学系, 教授 (80261337)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWASAKI Yasuaki 鹿児島大学, 農水産獣医学域獣医学系, 教授 (50211181)
YABUKI Akira 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (10315400)
MIURA Naoki 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (80508036)
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| Research Collaborator |
IWANAGA Tomoko 鹿児島大学, 共同獣医学部・動物病院, 特任助教
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 高齢性慢性疾患 / 遺伝子病 |
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| Outline of Final Research Achievements |
The objective of this study was to demonstrate that there are many adult-onset chronic genetic diseases in companion animals.
The reference range of canine and feline lysosomal enzymes was established to diagnose several lysosomal diseases. Using high-risk screening, mucopolysaccharidosis was diagnosed in three cats. One case was categorized in type VI by measurement of enzyme activities, and a causative mutation was identified in this cat. Adult-onset neuronal ceroid lipofuscinosis was diagnosed in two dogs. Early-onset hypertrophic cardiomyopathy was diagnosed in a cat.
Molecular epidemiological surveys were performed on feline mucopolysaccharidosis VI, feline pyruvate kinase deficiency, canine progressive retinal atrophy, and canine degenerative myelopathy. As a result, it was demonstrated that these diseases were present at a high frequency in the population of certain breeds, suggesting that these diseases are very important in veterinary clinics of companion animals.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Real-time PCR genotyping assay for canine progressive rod-cone degeneration and mutant allele frequency in Toy Poodles, Chihuahuas and Miniature Dachshunds in Japan.2016
Author(s)
Kohyama M, Tada N, Mitsui H, Tomioka H, Tsutsui T, Yabuki A, Rahman MM, Kushida K, Mizukami K, Yamato O.
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Journal Title
J Vet Med Sci
Volume: 78
Pages: 481-484
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 雑種猫の同腹2例に認められた神経セロイド・リポフスチン症.2015
Author(s)
田中啓之, 矢中雄一郎, 杉浦雄一, 中村孝行, 牛草貴博, 鳩谷晋吾, 内田和幸, 神山萌子, 矢吹映, 大和修.
Organizer
日本獣医学会
Place of Presentation
北里大学, 青森県十和田市
Year and Date
2015-09-07
Related Report
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[Presentation] 猫のβ-ウレイドプロピオナーゼ欠損症： その臨床、分子基盤および分子疫学.2015
Author(s)
清武典子, 飛田泰男, 松田広一, 張 春花, 新井 賢, 砂川一浩, 肥後隆志, 矢吹 映, 神山萌子, 櫛田和哉, 遠藤泰之, 大和 修.
Organizer
日本獣医師会年次大会
Place of Presentation
岡山コンベンションセンター（岡山県、岡山市）
Year and Date
2015-02-13 – 2015-02-15
Related Report
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