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Identification of genetic diseases of aged companion animals

Research Project

Project/Area Number 26660242
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Research InstitutionKagoshima University

Principal Investigator

Yamato Osamu  鹿児島大学, 農水産獣医学域獣医学系, 教授 (80261337)

Co-Investigator(Renkei-kenkyūsha) KAWASAKI Yasuaki  鹿児島大学, 農水産獣医学域獣医学系, 教授 (50211181)
YABUKI Akira  鹿児島大学, 農水産獣医学域獣医学系, 准教授 (10315400)
MIURA Naoki  鹿児島大学, 農水産獣医学域獣医学系, 准教授 (80508036)
Research Collaborator IWANAGA Tomoko  鹿児島大学, 共同獣医学部・動物病院, 特任助教
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords高齢性慢性疾患 / 遺伝子病
Outline of Final Research Achievements

The objective of this study was to demonstrate that there are many adult-onset chronic genetic diseases in companion animals.
The reference range of canine and feline lysosomal enzymes was established to diagnose several lysosomal diseases. Using high-risk screening, mucopolysaccharidosis was diagnosed in three cats. One case was categorized in type VI by measurement of enzyme activities, and a causative mutation was identified in this cat. Adult-onset neuronal ceroid lipofuscinosis was diagnosed in two dogs. Early-onset hypertrophic cardiomyopathy was diagnosed in a cat.
Molecular epidemiological surveys were performed on feline mucopolysaccharidosis VI, feline pyruvate kinase deficiency, canine progressive retinal atrophy, and canine degenerative myelopathy. As a result, it was demonstrated that these diseases were present at a high frequency in the population of certain breeds, suggesting that these diseases are very important in veterinary clinics of companion animals.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2016 2015 2014 2013

All Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Acknowledgement Compliant: 4 results,  Open Access: 3 results) Presentation (10 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Real-time PCR genotyping assay for canine progressive rod-cone degeneration and mutant allele frequency in Toy Poodles, Chihuahuas and Miniature Dachshunds in Japan.2016

    • Author(s)
      Kohyama M, Tada N, Mitsui H, Tomioka H, Tsutsui T, Yabuki A, Rahman MM, Kushida K, Mizukami K, Yamato O.
    • Journal Title

      J Vet Med Sci

      Volume: 78 Pages: 481-484

    • NAID

      130005140895

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] In situ detection of GM1 and GM2 gangliosides using immunohistochemical and immunofluorescent techniques for auxiliary diagnosis of canine and feline gangliosidoses.2016

    • Author(s)
      Kohyama M, Yabuki A, Ochiai K, Nakamoto Y, Uchida K, Hasegawa D, Takahashi K, Kawaguchi H, Tsuboi M, Yamato O.
    • Journal Title

      BMC Vet Res

      Volume: 12 Issue: 1 Pages: 64-64

    • DOI

      10.1186/s12917-016-0691-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Accumulation and aggregate formation of mutant superoxide dismutase 1 in canine degenerative myelopathy.2015

    • Author(s)
      Nakamae S, Kobatake Y, Suzuki R, Tsukui T, Kato S, Yamato O, Sakai H, Urushitani M, Maeda S, Kamishina H.
    • Journal Title

      Neuroscience

      Volume: 303 Pages: 229-240

    • DOI

      10.1016/j.neuroscience.2015.06.066

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Expression of autophagy-related proteins in the spinal cord of pembroke welsh corgi dogs with canine degenerative myelopathy.2015

    • Author(s)
      Ogawa M, Uchida K, Yamato O, Mizukami K, Chambers JK, Nakayama H.
    • Journal Title

      Veterinary Pathology

      Volume: 未定 Issue: 6 Pages: 1099-1107

    • DOI

      10.1177/0300985815570070

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Investigation of parallel and simultaneous selection for collie eye anomaly and ivermectin toxicosis.2014

    • Author(s)
      Mizukami K, Yabuki A, Endoh D, Chang HS, Lee KW, Nakayama M, Kushida K, Kohyama M, Lee JI, Yamato O.
    • Journal Title

      Veterinary Record

      Volume: 175 Issue: 7 Pages: 174-174

    • DOI

      10.1136/vr.102015

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Neuronal loss and decreased GLT-1 expression observed in the spinal cord of Pembroke Welsh Corgi dogs with canine degenerative myelopathy2013

    • Author(s)
      Ogawa M, Uchida K, Yamato O, Inaba M, Uddin MM, and Nakayama H
    • Journal Title

      Vet Pathol

      Volume: 51(3) Issue: 3 Pages: 591-602

    • DOI

      10.1177/0300985813495899

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 長毛雑種猫のムコ多糖症VI型における新規病原性変異の同定.2016

    • Author(s)
      神山萌子, 枝村一弥, 兼子祥紀, 矢吹映, 大和修.
    • Organizer
      日本獣医師会年次大会
    • Place of Presentation
      秋田キャッスルホテル, 秋田県秋田市
    • Year and Date
      2016-02-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Inborn errors of metabolism in dogs and cats: invitation for research collaration.2016

    • Author(s)
      Osamu Yamato.
    • Organizer
      The 7the Joint Symposium of Veterinariy Research among Universities of Veterinary Medicine.
    • Place of Presentation
      Green World Hotel, Tam Dao National Park, near Hanoi, Veitnum
    • Year and Date
      2016-02-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 雑種猫の同腹2例に認められた神経セロイド・リポフスチン症.2015

    • Author(s)
      田中啓之, 矢中雄一郎, 杉浦雄一, 中村孝行, 牛草貴博, 鳩谷晋吾, 内田和幸, 神山萌子, 矢吹映, 大和修.
    • Organizer
      日本獣医学会
    • Place of Presentation
      北里大学, 青森県十和田市
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 長毛雑種猫のムコ多糖症VI型における新規病原性変異の同定.2015

    • Author(s)
      神山萌子, 枝村一弥, 兼子祥紀, 矢吹映, 大和修.
    • Organizer
      日本獣医学会
    • Place of Presentation
      北里大学, 青森県十和田市
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 同腹兄弟雑種犬2例のクラッべ病におけるMRI所見と病理学的所見の比較検討.2015

    • Author(s)
      山添比奈子, 青木琴代, 内田和幸, 近藤広孝, 鈴木誠, 大和修.
    • Organizer
      日本獣医神経病学会
    • Place of Presentation
      大手町ファーストスクエア, 東京都千代田区
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 猫のβ-ウレイドプロピオナーゼ欠損症: その臨床、分子基盤および分子疫学.2015

    • Author(s)
      清武典子, 飛田泰男, 松田広一, 張 春花, 新井 賢, 砂川一浩, 肥後隆志, 矢吹 映, 神山萌子, 櫛田和哉, 遠藤泰之, 大和 修.
    • Organizer
      日本獣医師会年次大会
    • Place of Presentation
      岡山コンベンションセンター(岡山県、岡山市)
    • Year and Date
      2015-02-13 – 2015-02-15
    • Related Report
      2014 Research-status Report
  • [Presentation] ETFDH遺伝子点変異によるグルタル酸尿症Ⅱ型発症ネコの解析.2014

    • Author(s)
      吉野大輝, 脇谷晶一, 鳥巣至道, 八反田和寿, 大和 修, 田崎隆二, 藤田春雄, 西野光一郎.
    • Organizer
      日本獣医学会
    • Place of Presentation
      北海道大学(北海道、札幌市)
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 国内純血種猫集団における赤血球ピルビン酸キナーゼ欠損症の病原性変異アレル頻度.2014

    • Author(s)
      櫛田和哉, Urs Giger, 因幡恵美, 今野喜夫, 林くれは, 野口佳那, 矢吹 映, 水上圭二郎, 神山萌子, 大和 修.
    • Organizer
      日本獣医学会
    • Place of Presentation
      北海道大学(北海道、札幌市)
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 犬の変性性脊髄症における呼吸機能の経時的変化.2014

    • Author(s)
      小宅香苗, 小畠 結, 柴田早苗, 大和 修, 前田貞俊, 神志那弘明.
    • Organizer
      中部地区獣医師会
    • Place of Presentation
      ホテルセンチュリー静岡(静岡県、静岡市)
    • Year and Date
      2014-08-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 犬変異型SOD1遺伝子へテロ接合体の病理組織学的特徴.2014

    • Author(s)
      小畠 結, 酒井洋樹, 大和 修, 前田貞俊, 神志那弘明.
    • Organizer
      中部地区獣医師会
    • Place of Presentation
      ホテルセンチュリー静岡(静岡県、静岡市)
    • Year and Date
      2014-08-31
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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