| Project/Area Number |
26660242
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Kagoshima University |
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Principal Investigator |
Yamato Osamu 鹿児島大学, 農水産獣医学域獣医学系, 教授 (80261337)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWASAKI Yasuaki 鹿児島大学, 農水産獣医学域獣医学系, 教授 (50211181)
YABUKI Akira 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (10315400)
MIURA Naoki 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (80508036)
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| Research Collaborator |
IWANAGA Tomoko 鹿児島大学, 共同獣医学部・動物病院, 特任助教
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 高齢性慢性疾患 / 遺伝子病 |
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| Outline of Final Research Achievements |
The objective of this study was to demonstrate that there are many adult-onset chronic genetic diseases in companion animals.
The reference range of canine and feline lysosomal enzymes was established to diagnose several lysosomal diseases. Using high-risk screening, mucopolysaccharidosis was diagnosed in three cats. One case was categorized in type VI by measurement of enzyme activities, and a causative mutation was identified in this cat. Adult-onset neuronal ceroid lipofuscinosis was diagnosed in two dogs. Early-onset hypertrophic cardiomyopathy was diagnosed in a cat.
Molecular epidemiological surveys were performed on feline mucopolysaccharidosis VI, feline pyruvate kinase deficiency, canine progressive retinal atrophy, and canine degenerative myelopathy. As a result, it was demonstrated that these diseases were present at a high frequency in the population of certain breeds, suggesting that these diseases are very important in veterinary clinics of companion animals.
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