| Project/Area Number |
26670001
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Masanori 金沢大学, 医薬保健研究域薬学系, 准教授 (80453835)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Asymmetric induction / Carbocations / カルボカチオン / 不斉アルキル化 / 脱離基 / 脱水縮合剤 |
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| Outline of Final Research Achievements |
Asymmetric induction utilizing highly reactive carbocations is an attractive and challenging theme. We hypothesized that if an optically active asymmetric ether coordinates to a prochiral carbocation in a face-selective manner, stereoselectivity can be achieved in alkylation of nucleophiles. As a result, we succeeded in development of various reagents that enable to generate carbocationic species available for the study of asymmetric induction. In addition, in a Friedel-Crafts reaction using phenethylcationic species in the presence of an asymmetric ether, we observed asymmetric induction even though the selectivity was insufficient.
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