| Project/Area Number |
26670006
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 酸化 / 不斉合成 / イオン対 / マンガン / ラクトン / 位置選択性 / 鉄 / 過酸化水素 / C-H結合 |
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| Outline of Final Research Achievements |
In this project, we planned to use a concept of chiral ion-pairing to construct unique chiral environment around an oxidation catalyst toward the development of selective C-H oxidation transformations. First, iron or manganese-N5 complexes having chiral counter anions such as chiral phosphates and sulfonates were synthesized. Probably due to slow exchange rate of the counter anion, oxidation was retarded considerably. In contrast, CH oxidation proceeded in using a N4 ligand. When alkane with a carboxylic acid as a directing group was employed, the oxidation occurred at the benzylic position in good yield, affording the corresponding lactones with moderate enantioselectivity.
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