| Project/Area Number |
26670008
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 機能性分子 / 人工DNA / 分岐型DNA / 包接化合物 / 超分子化学 / 分子カプセル / 三量体DNA / 分子認識 / 蛍光 / インターカレーション / 会合体 / 人工核酸 / 包接 / 分岐型核酸 / 会合体形成 |
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| Outline of Final Research Achievements |
The DNA double helix is held together by complementary base pairing stabilized by hydrogen bonds. However, chemical synthesis of a branched form of DNA act as a unit molecule, will facilitate the formation of a variety of nucleic acid structures other than the double helix. In this study, we designed and synthesized novel threefold-symmetric branched DNA molecules containing 1, 3, 5-trisubstituted benzene as a planar central unit. The properties of the synthetic DNA molecules were then studied, which revealed a novel ability of the branched DNA species to complex with guest molecules. Structural properties of the complex were analyzed using spectroscopic measurements as well as computer simulation methods, which demonstrated the formation of a novel three-component complex.
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