Strategic regulation of molecular ensembles via programmed hybridization of smart catalysts
| Project/Area Number |
26670009
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Microbial Chemistry Research Foundation |
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Principal Investigator |
KUMAGAI Naoya 公益財団法人微生物化学研究会, 微生物化学研究所, 主席研究員 (40431887)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 有機化学 / ハイブリダイゼーション / 触媒 / 分子アンサンブル / 水素結合 / アゾベンゼン / フォールディング / 光異性化 |
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| Outline of Final Research Achievements |
Azobenzene derivatives bearing complementary triple hydrogen bonding units on both sides have been designed and synthesized. UV irradiation of trans-compounds induced photoisomerization to cis-compounds, whose structure was characterized by folded globular conformation owing to intramolecular hydrogen bonding interactions. The folded structure was evident by 2D-NMR and size-exclusion chromatography. Structure and length of the linker connecting the azobenzen and the hydrogen bonding units are determinants for successful folding and unfolding. Intriguingly, introduction of a stereogenic center on the linker rendered the folding process enantiosleective, leveraging chiroptical property of the phtoresponsive compounds.
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Report
(3 results)
Research Products
(6 results)
