| Project/Area Number |
26670010
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
ANZAI Jun-ichi 東北大学, 薬学研究科(研究院), 教授 (40159520)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Katsuhiko 東北大学, 大学院薬学研究科, 助教 (80400266)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | グルコースセンサー / フェニルボロン酸 / フェロセン |
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| Outline of Final Research Achievements |
Non-enzymatic glucose sensors without enzymes were developed by modifying the surface of electrodes with glucose-sensitive synthetic molecules.The synthetic molecules are composed of glucose-binding phenylboronic acid moiety and redox-active ferrocene group. Glucose sensors were prepared by immobilizing the compounds on metal electrode. In cyclic voltammetry and differential pulse voltammetry, the modified electrode showed redox waves at approximately 0.3 V, which were sensitive to glucose and fructose at pH 7.0-9.0. The glucose sensors exhibited the electrochemical response to glucose in the concentration range of 1-20 mM, suggesting potential application of the sensors to the determination of blood glucose.
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