| Project/Area Number |
26670011
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
Hideo Saji 京都大学, 薬学研究科(研究院), 教授 (40115853)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Hiroyuki 京都薬科大学, 薬学部, 准教授 (50437240)
TEMMA Takashi 国立研究開発法人国立循環器病研究センター, 室長 (90378787)
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| Co-Investigator(Renkei-kenkyūsha) |
ONO Masahiro 京都大学, 薬学研究科(研究院), 准教授 (80336180)
SANO Kohei 京都大学, 医学(系)研究科(研究院), 助教 (00546476)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | イメージング / チェレンコフ光 / 内用放射線治療 |
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| Outline of Final Research Achievements |
The purpose of this study is to establish a novel in vivo Cherenkov imaging methods for evaluating the effect of internal radiation therapy. Anti-EGFR monoclonal antibody was labeled with Cu-64 and Y-90, and in vivo Cherenkov imaging was performed in tumor-bearing mice. In vivo biodistribution of radioactivity was detected by Cherenkov imaging for both probes, but for tumor imaging, antibody labeled with Y-90, which has long half-life compared to Cu-64, clearly visualized tumor tissues. Signal intensity in each tissue was correlated with in vivo biodistribution of radioactivity, therefore, Cherenkov imaging has a potential for predicting biodistribution of 90Y-labeled antibody for evaluating the effect of internal radiation therapy.
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