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Development of DDS applicable for immune therapy by using self-assembling RNA sponge particle

Research Project

Project/Area Number 26670013
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Physical pharmacy
Research InstitutionKyoto University

Principal Investigator

Takakura Yoshinobu  京都大学, 薬学研究科(研究院), 教授 (30171432)

Co-Investigator(Kenkyū-buntansha) NISHIKAWA Makiya  京都大学, 大学院薬学研究科, 准教授 (40273437)
TAKAHASHI Yuki  京都大学, 大学院薬学研究科, 助教 (00547870)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsドラッグデリバリー / アジュバント / ワクチン / TLR3
Outline of Final Research Achievements

In the present study, we selected magnesium pyrophosphate particle (MgPP), and loaded polyI:C, an immunostimulatory nucleic acid, to MgPP to develop an adjuvant system. PolyI:C was loaded to MgPP by adding polyI:C to the MgPP preparation step. Loading polyI:C to MgPP enhanced the uptake of polyI:C by immune cells and following cytokine release. Moreover, the addition of polyI:C-loaded MgPP containing an antigen to dendritic cells resulted in improved antigen presentation.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results)

  • [Journal Article] Application of magnesium pyrophosphate-based sponge-like microparticles to enhance the delivery efficiency and adjuvant effects of polyriboinosinic-polyribocytidylic acid in immune cells.2016

    • Author(s)
      Takagi S, Takahashi Y, Sugimura K, Nishikawa M, Takakura Y.
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 105 Issue: 2 Pages: 766-772

    • DOI

      10.1016/j.xphs.2015.11.020

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] ピロリン酸マグネシウム微粒子を用いた免疫アジュバントのデリバリー2015

    • Author(s)
      高木翔一、高橋有己、杉村佳那子、西川元也、高倉喜信
    • Organizer
      第65回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪大谷大学 (大阪府 富田林市)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] ピロリン酸マグネシウム粒子を用いたワクチンシステムの開発2015

    • Author(s)
      高木翔一、高橋有己、杉村佳那子、西川元也、高倉喜信
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸サンボーホール(神戸)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 核酸搭載ピロリン酸マイクロスポンジを利用した免疫アジュバントの開発2014

    • Author(s)
      高木翔一、高橋有己、杉村佳那子、西川元也、高倉喜信
    • Organizer
      日本バイオマテリアル学会 第9回関西若手研究発表会
    • Place of Presentation
      京都大学船井哲良記念講堂(京都)
    • Year and Date
      2014-08-05
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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