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Detection of cancer stem cells and minimal invasion by DNP-MRI and hyperspectral enodoscopy redox imaging

Research Project

Project/Area Number 26670016
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Physical pharmacy
Research InstitutionKyushu University

Principal Investigator

NAKANO Kenji  九州大学, 先端融合医療レドックスナビ研究拠点, 教授 (00315061)

Co-Investigator(Kenkyū-buntansha) HYODO Fuminori  九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (10380693)
MURATA Masaharu  九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (30304744)
HASHIZUME Makoto  九州大学, 医学系研究院, 教授 (90198664)
CUI Lin  九州大学, 先端融合医療レドックスナビ研究拠点, 特任助教 (30717822)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords分子イメージング / ハイパースペクトル内視鏡 / レドックス / 微小癌浸潤診断 / 癌幹細胞 / ハイパースペクトル
Outline of Final Research Achievements

The purpose of this study is to develop the non-invasive method for detecting minimal cancer invasion and cancer stem-like cells using hyperspectral endoscopic and DNP-MRI redox (metabolic) imaging technologies.
The eraly diagnosis for minimal disseminated cancers is difficult by conventional MRI, because it is difficult to discriminate the density between small volume of malignant ascites and tissue water components at the early stage of cancer progression. We have herewith met in success to develop the analysis method using DNP-MRI that visualize a minimal volume of malignant ascites as a diagnosis marker for early stage of peritoneal dissemination. Hyperspectral imaging discriminated high vascular flow and low-oxigen concentration in subcutaneous tumors from the surrounding normal counterparts.
These results indicate the potential of DNP-MRI and hyperspectral endoscope imaging as an useful diagnosis modalities for minimal cancer invasion and dissemination.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 3 results) Presentation (2 results) (of which Invited: 2 results)

  • [Journal Article] Selective Imaging of Malignant Ascites in a Mouse Model of Peritoneal Metastasis Using in Vivo Dynamic Nuclear Polarization-Magnetic Resonance Imaging.2016

    • Author(s)
      Eto H, Hyodo F, Nakano K, Utsumi H.
    • Journal Title

      Analytic Chemistry

      Volume: 88 Issue: 4 Pages: 2021-27

    • DOI

      10.1021/acs.analchem.5b04821

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Expression and characterization of myristoylated preS1-conjugated nanocages for targeted cell delivery2015

    • Author(s)
      Murata M, Piao JS, Narahara S, Kawano T, Hamano N Kang J-H, Asai D, Ugawa R, Hashizume M
    • Journal Title

      Protein Expression and Purification

      Volume: 110 Pages: 52-56

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Design and function of engineered protein nanocages as a drug delivery system for targeting pancreatic cancer cells via neuropilin-12015

    • Author(s)
      Masaharu Murata, Sayoko Narahara, Takahito Kawano, Nobuhito Hamano, Jing Shu Piao, Jeong-Hun Kang, Kenoki Ohuchida, Takashi Murakami, Makoto Hashizume
    • Journal Title

      Molecular Pharmaceutics

      Volume: in press Issue: 5 Pages: 1422-1430

    • DOI

      10.1021/mp5007129

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 生体動的核偏極(DNP)-MRIを用いた新たなレドックスイメージング法の開発と応用2015

    • Author(s)
      兵藤 文紀
    • Organizer
      第43回日本共鳴医学会 シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 磁気共鳴イメージングによる新たなレドックス代謝イメージング法の開発2015

    • Author(s)
      兵藤 文紀
    • Organizer
      日本分析化学会第64年会 シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
    • Invited

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Published: 2014-04-04   Modified: 2017-05-10  

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