Screening for proteasome-activating compounds that could cure neurodegenerative diseases

Research Project

Project/Area Number	26670022
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Biological pharmacy
Research Institution	The University of Tokyo
Principal Investigator	Murata Shigeo 東京大学, 薬学研究科(研究院), 教授 (20344070)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	プロテアソーム / 変性タンパク質 / タンパク質分解 / 神経変性疾患 / SOD1 / タウ / 低分子化合物 / スクリーニング / 創薬
Outline of Final Research Achievements	To develop a drug that can cure neurodegenerative diseases, we screened a chemical library for small molecules that activate proteasomes and promote degradation of misfolded proteins observed in neurodegenerative diseases such as SOD1, tau, and α-synuclein, and identified several promising compounds.