| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Outline of Final Research Achievements |
The endogenous circadian clock drives daily oscillations in physiology and behavior. We are not usually aware of this system because it is completely synchronized with environmental light-dark cycles, but travelling rapidly across multiple time zones suddenly makes us aware of the desynchrony, causing sleep disturbances. Repeated jet-lag exposure increases the risk of lifestyle-related diseases, such as cardiovascular complaints. Especially, shiftworkers, who chronically experience jet lag socially due to rotated work-time schedules, have been shown to have a high risk in not only mental diseases but also cancer, diabetes, and obesity. However, little is known about the molecular and neural mechanisms of jet lag. We have recently revealed that mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag. Thus, our aim is to elucidate the fundamental mechanisms about jet lag and develop a remedy for shiftwork-related problems using non-jet-lag mice.
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