Brain mast cells as a novel drug target
| Project/Area Number |
26670029
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
Tanaka Satoshi 岡山大学, 医歯(薬)学総合研究科, 教授 (40303846)
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| Co-Investigator(Kenkyū-buntansha) |
FURUTA Kazuyuki 岡山大学, 大学院医歯薬学総合研究科, 准教授 (50644936)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIMOTO Yukihiko 熊本大学, 大学院生命科学研究部, 教授 (80243038)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | マスト細胞 / 遺伝子発現 / クロモグリク酸ナトリウム / 神経成長因子 / TrkA |
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| Outline of Final Research Achievements |
We focused on brain mast cells to clarify how inflammatory responses promote cerebrovascular diseases and dementia. We revealed the gene expression profiles specific to murine brain mast cells and determined the mechanism by which activated mast cells acquire sensitivity to nerve growth factor. We, furthermore, identified the target molecule of disodium cromoglycate, which was found to suppress histamine release from activated mast cells.
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Report
(3 results)
Research Products
(7 results)
