Lipid mediators and mast cells are involved in M2 macrophage accumulation and spinal injury repair
| Project/Area Number |
26670030
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
Sugimoto Yukihiko 熊本大学, 大学院生命科学研究部(薬), 教授 (80243038)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | プロスタグランジン / M2マクロファージ / 脊髄損傷 / 脈絡叢 / マスト細胞 / ケモカイン / マクロファージ / 分化 |
|---|
| Outline of Final Research Achievements |
In spinal injury, the peripheral macrophages enter into injured sites. It has been shown that M1 and M2 pass through spinal blood vessels and choroid plexus, respectively. M2 differentiation occurs when peripheral macrophages pass through choroid plexus, and such accumulated M2 cells play roles in injury repair. Based on the previously obtained results, we hypothesized that mast cells around the choroid plexus regulate M2 differentiation and spinal repair in a lipid mediator-dependent manner and explored it. We obtained data suggesting involvement of mast cells and prostaglandin in these processes.
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Report
(5 results)
Research Products
(50 results)
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[Journal Article] Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity.2017
Author(s)
Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo M, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.
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Journal Title
Cancer Discov
Volume: in press
Issue: 5
Pages: 522-538
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior.2016
Author(s)
Yabuki Y, Koide T, Miyasaka N, Wakisaka N, Masuda M, Ohkura M, Nakai J, Tsuge K, Tsuchiya S, Sugimoto Y, Yoshihara Y
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Journal Title
Nature Neuroscience
Volume: 19
Issue: 7
Pages: 897-904
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Peer Reviewed / Open Access
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[Journal Article] Dermal Vγ4(+) γδ T Cells Possess a Migratory Potency to the Draining Lymph Nodes and Modulate CD8(+) T-Cell Activity through TNF-α Production.2015
Author(s)
Nakamizo S, Egawa G, Tomura M, Sakai S, Tsuchiya S, Kitoh A, Honda T, Otsuka A, Nakajima S, Dainichi T, Tanizaki H, Mitsuyama M, Sugimoto Y, Kawai K, Yoshikai Y, Miyachi Y, Kabashima K.
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Journal Title
Journal of Investigative Dermatology
Volume: 135
Issue: 4
Pages: 1007-1015
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice2015
Author(s)
Ikeda K, Tomimoto S, Tsuchiya S, Hamagami K, Shintani N, Sugimoto Y, Ichikawa A, Kasai A, Nakazawa T, Nagayasu K, Hayata-Takano A, Baba A, Hashimoto H
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Journal Title
Biochim Biophys Rep
Volume: 2
Pages: 179-183
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling that Drives Tumor Growth, Angiogenesis and Metastasis.2015
Author(s)
Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, Hirata M, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C.
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Journal Title
J Biol Chem.
Volume: 290
Issue: 50
Pages: 29781-93
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Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin.2014
Author(s)
Natsuaki Y, Egawa G, Nakamizo S, Ono S, Hanakawa S, Okada T, Kusuba N, Otsuka A, Kitoh A, Honda T, Nakajima S, Tsuchiya S, Sugimoto Y, Ishii KJ, Tsutsui H, Yagita H, Iwakura Y, Kubo M, Ng Lg, Hashimoto T, Fuentes J, Guttman-Yassky E, Miyachi Y, Kabashima K
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Journal Title
Nature Immunology
Volume: 15
Issue: 11
Pages: 1064-9
DOI
Related Report
Peer Reviewed
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[Journal Article] 12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor.2014
Author(s)
Liu M, Saeki K, Matsunobu T, Okuno T, Koga T, Sugimoto Y, Yokoyama C, Nakamizo S, Kabashima K, Narumiya S, Shimizu T, Yokomizo T
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Journal Title
J Exp Med
Volume: 211
Issue: 6
Pages: 1063-1078
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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