Genes that enable high-efficiency gene disruption in human cells
| Project/Area Number |
26670031
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Yokohama City University |
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Principal Investigator |
Adachi Noritaka 横浜市立大学, 生命ナノシステム科学研究科(八景キャンパス), 教授 (30264675)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ゲノム改変 / ジーンターゲティング / Nalm-6 |
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| Outline of Final Research Achievements |
In this research project, we have identified several human genes that increase the efficiency of gene targeting by homologous recombination. We have shown for the first time that an enzyme with cytidine deaminase activity can enhance gene targeting in NHEJ-null cells.
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Report
(3 results)
Research Products
(5 results)
