Research Project
Grant-in-Aid for Challenging Exploratory Research
Chondroitin sulfate, a long linear polysaccharide that is covalently bound to specific core proteins to form chondroitin sulfate proteoglycans, is distributed on the cell surfaces and in the extracellular matrix. To date, chondroitin sulfate proteoglycans have been reported to play important roles in physiological processes, such as cell-cell interactions, cell proliferation, differentiation, and morphogenesis. Many of the physiological roles are attributed to the chondroitin sulfate side chains. We previously reported that mutant mice completely lacking chondroitin sulfate side chains result in embryonic lethality before the 8-cell stage due to incomplete cytokinesis and that chondroitin sulfate side chains are indispensable for embryonic cell division. In this study, we showed that the decreased amount of chondroitin sulfate with age might lead to suppression of follicular maturation.
All 2017 2016 2015 2014 Other
All Journal Article (1 results) (of which Peer Reviewed: 1 results, Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 3 results, Invited: 6 results) Book (3 results) Remarks (2 results)
J. Biol. Chem.
Volume: 291 Issue: 44 Pages: 23294-23304
10.1074/jbc.m116.757328
http://kpubiochem.firebird.jp/
http://www.kobepharma-u.ac.jp/~biochem/
