Involvement of the decreased chondroitin sulfate production in the presence of multinucleated blastomeres
Project/Area Number |
26670033
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Biological pharmacy
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Research Institution | Kobe Pharmaceutical University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
SATO Ban 筑波大学, 生命環境系生物科学分野, 特任助教 (90443126)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | コンドロイチン硫酸 / 多核形成 / 加齢 / プロテオグリカン / 糖転移酵素 / 細胞外マトリックス / エストラジオール / 不妊 / 細胞外マトリクス / 卵胞成熟過程 / 卵巣 |
Outline of Final Research Achievements |
Chondroitin sulfate, a long linear polysaccharide that is covalently bound to specific core proteins to form chondroitin sulfate proteoglycans, is distributed on the cell surfaces and in the extracellular matrix. To date, chondroitin sulfate proteoglycans have been reported to play important roles in physiological processes, such as cell-cell interactions, cell proliferation, differentiation, and morphogenesis. Many of the physiological roles are attributed to the chondroitin sulfate side chains. We previously reported that mutant mice completely lacking chondroitin sulfate side chains result in embryonic lethality before the 8-cell stage due to incomplete cytokinesis and that chondroitin sulfate side chains are indispensable for embryonic cell division. In this study, we showed that the decreased amount of chondroitin sulfate with age might lead to suppression of follicular maturation.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Chondroitin 4-O-sulfotransferase is indispensable for sulfation of chondroitin and plays an important role in maintaining normal life span and oxidative stress responses in nematodes.2016
Author(s)
Izumikawa, T., Dejima, K., Watamoto, Y., Nomura, K. H., Kanai, N., Rikitake, M., Tou, M., Murata, D., Yanagita, E., Kano, A., Mitani, S., Nomura, K., and Kitagawa, H.
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Journal Title
J. Biol. Chem.
Volume: 291
Issue: 44
Pages: 23294-23304
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Book] Sulfated Polysaccharides (Gama, M., Nader, H., and de Oliveira Rocha, H., eds)2015
Author(s)
Tomatsu, S., Shimada, T., Patel, P., Mason, R. W., Mikami, T., Kitagawa, H., Montano, A. M., and Orii, T.
Total Pages
317
Publisher
Nova Science Publishers
Related Report
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[Book] Handbook of Glycosyltransferases and Related Genes, 2nd Ed (Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., and Angata, T., eds)2014
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