| Project/Area Number |
26670035
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TOMITA Taisuke 東京大学, 薬学研究科(研究院), 教授 (30292957)
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| Project Period (FY) |
2014-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | プロテアーゼ / シナプス / EphA4 |
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| Outline of Final Research Achievements |
To elucidate the molecular mechanisms how monoaminergic synapses are generated and maintained, we have analyzed the synaptogenic activity and metabolism of EphA4 receptor, which is known as a synaptic organizer membrane protein. We found that EphA4 is shed by membrane-bound metalloprotease ADAM10 that is activated by dopamine D2 receptor. Proteolytic fragment of EphA4 is capable to generate synapses. Thus, we hypothesized that ADAM10-mediated shedding of EphA4 by dopamine D2 receptor activation would lead to generate new dopaminergic synapses.
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