Development of lead commands for new anti-infective agents
| Project/Area Number |
26670043
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 抗菌薬 / 化合物ライブラリー / カイコ / 作用機序解析 / 感染症 |
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| Outline of Final Research Achievements |
We evaluated antimicrobial activity and mechanistic analysis of the compounds which identified by therapeutic effectiveness on silkworm infection model. These compounds showed antimicrobial activity against Staphylococci, and one of compound showed prolonged proliferation activity on mouse systemic infection model. This compound is implied to have a novel mechanism. These results suggest that silkworm infection model is useful model to identity therapeutically effective antimicrobial compounds from synthetic compounds library.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis.2015
Author(s)
Ishii K, Tabuchi F, Matsuo M, Tatsuno K, Sato T, Okazaki M, Hamamoto H, Matsumoto Y, Kaito C, Aoyagi T, Hiramatsu K, Kaku M, Moriya K, Sekimizu K.
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Journal Title
Sci Rep
Volume: 5
Issue: 1
Pages: 17092-17092
DOI
Related Report
Peer Reviewed / Open Access
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