| Project/Area Number |
26670044
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | University of Toyama |
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Principal Investigator |
Tohda Chihiro 富山大学, 和漢医薬学総合研究所, 准教授 (10272931)
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| Co-Investigator(Kenkyū-buntansha) |
紺野 勝弘 富山大学, 和漢医薬学総合研究所, 客員教授 (40215471)
数馬 恒平 富山大学, 和漢医薬学総合研究所, 客員助教 (70552446)
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| Co-Investigator(Renkei-kenkyūsha) |
KUBOYAMA Tomoharu 富山大学, 和漢医薬学総合研究所, 助教 (10415151)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 脊髄損傷 / 骨格筋萎縮 / 軸索修復 / 運動ニューロン / 生薬 / マイクログリア / 骨格筋細胞 / 軸索 / 皮質脊髄路 / 介在ニューロン |
|---|
| Outline of Final Research Achievements |
We explored effective crude drugs that improved motor function of spinal cord injured mice when administered at chronic phase after injury. Water extracts of Cistanche Herba and Sophorae Radix showed significant effects. The extract of Cistanche Herba enhanced proliferation of myocytes and released novel axonal growth factors. The water extract of Sophorae Radix extended axons even on CSPG-coated dishes. Matrine was identified as active compound in the extract. A comprehensive analysis of direct binding molecule of matrine, indicated that HSP90 bound to matrine. The binding increased chaperone activity of HSP90.
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