| Project/Area Number |
26670045
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | Kochi University |
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Principal Investigator |
TSUDA Masashi 高知大学, 教育研究部総合科学系, 教授 (10261322)
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| Co-Investigator(Kenkyū-buntansha) |
OGURA Kenji 石川県立大学, 生物資源環境学部, 教授 (50270682)
ULANOVA Dana 高知大学, 教育研究部総合科学系, 助教 (70610129)
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| Project Period (FY) |
2014-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | マクロリド / 殺細胞活性 / 細胞増殖促進活性 / 渦鞭毛藻 / 動的核偏極 |
|---|
| Outline of Final Research Achievements |
Marine dinoflagellates of the genus Amphidinium have been recognized as a valuable source of unique macrolides possessing exhibiting potently cytotoxic activity. In this study, the investigation for molecular targets of the cytotoxic macrolide, iriomoteolide-1a, resulted in affinity for tubulin. Furthermore, we isolated two new compounds, amphirionin-4 with potent cell proliferation-promoting activity and iriomoteolide-2a, a 23-membered macrolide with cytotoxic activity, and their structures with absolute stereochemistries were elucidated.
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