| Project/Area Number |
26670049
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | Kitasato University |
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Principal Investigator |
Miura Hiromi 北里大学, 感染制御科学府, 助教 (20462252)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Atsuko 北里大学, 感染制御科学府, 講師 (20300759)
NAKASHIMA Takuji 北里大学, 北里生命科学研究所, 特任准教授 (40526216)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Yōko 北里大学, 感染制御科学府, 研究員 (80197186)
SHIOMI Kazuro 北里大学, 感染制御科学府, 教授 (40235502)
IWATSUKI Masato 北里大学, 感染制御科学府, 講師 (70353464)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 抗結核菌物質 / 放線菌 / 微生物培養抽出液 / 二次代謝産物 / 抗結核菌作用 / 糸状菌 / 抗結核菌 |
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| Outline of Final Research Achievements |
To discover anti-tuberclosis drugs with a new mechanisms of action, we invented simple screening system that is targeted to biosynthesis pathway of diaminopimelate (DAP). We screened approximately 9,600 culture broths of actinomycete and fungi. As a result, we found anti-mycobacterium substance produced by Streptomyces sp. K12-0214. This substance is water-soluble, irreversibly inactivated under basic condition. Anti-microbial spectrum of this material was different from that of existing drug isoniadide and rifampicin.
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