| Project/Area Number |
26670058
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
Otsuka Masami 熊本大学, 大学院生命科学研究部(薬学系), 教授 (40126008)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJITA MIKAKO 熊本大学, 薬学部, 准教授 (00322256)
OKAMOTO YOSHINARI 熊本大学, 大学院生命科学研究部, 助教 (20194409)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アルツハイマー病 / アミロイドβ / 亜鉛キレーター / scyllo-イノシトール |
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| Outline of Final Research Achievements |
The objective of the present study is to design and synthesis of a compound aiming at the cure of Alzheimer’s disease based on the amyloid hypothesis that the aggregation of amyloid beta (Ab) in the brain is the main cause of Alzheimer’s disease. It is known that zinc released from synaptic termini accelerate the aggregation of Ab. It is also known that scyllo-inositol inhibit the Ab aggregation. Therefore, combination of zinc-binding compound and scyllo-inositol would suppress the Ab aggregation. The present study aimed at the synthesis of an artificial compound comprising zinc chelator and scyllo-inositol.
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