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Development of mutant IFN-alpha as a drug against the chemo-resistance of cancer stem cells

Research Project

Project/Area Number 26670061
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Drug development chemistry
Research Institution独立行政法人医薬基盤研究所

Principal Investigator

TSUNODA Shin-ichi  独立行政法人医薬基盤研究所, 創薬基盤研究部, プロジェクトリーダー (90357533)

Project Period (FY) 2014-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywordscancer stem cell / IFN-alpha / phage display library / 蛋白質 / バイオ医薬 / がん
Outline of Final Research Achievements

For advancement of cancer chemotherapy, development of a novel method to attack the cancer stem cells (CSCs) which are resistant to anticancer drugs is needed. Resistance to chemotherapy of CSCs is depends on their dormant state of cell cycle. Recent study revealed that such a dormant state of cell cycle of stem cells was caused by inhibition of IFN-α signal transduction. This suggests the possibility that potent IFN-α signal may remove the chemo-resistance of CSCs. In order to investigate the above hypothesis, we tried to produce IFN-α mutants of high bioactivity and cell cycling activity for stimulate the cell cycle of CSCs. To this end, we performed a screening of IFN-α8 mutants by our original technology creating functional cytokine mutants using phage display library system. By using our technology, several potential IFN-α8 mutants have been successfully isolated. These IFN-α mutants could be a promising adjuvant for cancer chemotherapy.

Report

(2 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (2 results)

All 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results) (of which Invited: 1 results)

  • [Journal Article] Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.2015

    • Author(s)
      Inoue M., Tsunoda S. et al.
    • Journal Title

      J. Cell Sci.

      Volume: 128 Pages: 656-669

    • DOI

      10.1242/jcs.149385

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] サイトカインとタンパク質工学による粘膜ワクチンアジュバント開発2014

    • Author(s)
      角田慎一
    • Organizer
      日本DDS学会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-07-31
    • Related Report
      2014 Annual Research Report
    • Invited

URL: 

Published: 2014-04-04   Modified: 2016-06-03  

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