Exploitation of pathogenic gastrointestinal bacteria specific molecular tageting therapy

• Project/Area Number: 26670065
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental and hygienic pharmacy
• Research Institution: Keio University
• Principal Investigator: Suzuki Hidekazu 慶應義塾大学, 医学部, 教授 (70255454)
• Co-Investigator(Kenkyū-buntansha): SAKAKIBARA YASUBUMI 慶應義塾大学, 理工学部, 教授 (10287427) ; TSUGAWA HITOSHI 慶應義塾大学, 医学部, 助教 (30468483)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: Helicobacter pylori / 鉄 / FecA1 / 除菌療法 / 酸化ストレス / in silico / メトロニダゾール / H. pylori / NDGA

Outline of Final Research Achievements

Superoxide dismutase (SodB) of H. pylori plays an indispensable role in the development of drug resistance against metronidazole. The activation of SodB requires Fe2+ supply through FecA1, suggesting that FecA1 is a possible target for a novel eradication therapy. By in silico screening, we explored FecA1-binding compounds and identified nordihydroguaiaretic acid (NDGA), that reduced intrabacterial Fe2+ levels and SodB activity and then increased the H2O2 sensitivity to the same levels observed in fecA1-deletion mutants. NDGA decreased the colonization density of H. pylori in the mouse stomach, indicating the repression of gastric mucosal-colonization of H. pylori via inhibition of intracellular Fe2+ uptake by FecA1. In addition, NDGA also increased the in vitro H2O2 sensitivity of Salmonella typhimurium and enteropathogenic E. coli. These results suggest that NDGA might be effective for the development of a novel therapy selectively against inflammogenic enteropathogenic bacteria.

Research Products

• [Journal Article] A prospective study on symptom generation according to spicy food intake and TRPV1 genotypes in functional dyspepsia patients. (2016)
  • Author(s): Lee, S-Y., Masaoka, T., Han, H-S., Matsuzaki, J., Hong, M-J., Fukuhara, S., Choi, H-S, Suzuki, H.
  • Journal Title: Neurogastroenterol. Motil. Volume: -
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of regular exercise on gastric emptying in healthy men: a pilot study. (2016)
  • Author(s): Matsuzaki, J., Suzuki, H.*, Masaoka, T., Tanaka, K., Mori, H., Kanai, T.
  • Journal Title: J. Clin. Biochem. Nutri. Volume: -
  • NAID: 130005262393
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Profile of acotiamide in the treatment of functional dyspepsia. (2016)
  • Author(s): Ueda, M., Iwasaki, E., Suzuki H.
  • Journal Title: Clin. Exp. Gastroenterol. Volume: 9 Pages: 83-88
  • DOI: 10.2147/ceg.s72172
  • Peer Reviewed / Open Access
• [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). (2016)
  • Author(s): Klionsky, D.J., Abdelmohsen, K., Abe, A., Abedin, M.J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C.M., Suzuki, H. et al.
  • Journal Title: Autophagy Volume: 12 Pages: 1-222
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Family history is an independent risk factor for the progression of gastric atrophy among patients with Helicobacter pylori infection. (2016)
  • Author(s): Nishizawa, T., Suzuki, H., Sakitani, K., Yamashita, H., Yoshida, S., Hata, K., Kanazawa, T., Fujiwara, N., Kanai, T., Yahagi, N., Toyoshima, O.
  • Journal Title: United European Gastroenterology Journal Volume: - Issue: 1 Pages: 32-36
  • DOI: 10.1177/2050640616642341
  • Peer Reviewed / Open Access
• [Journal Article] Endoscopic slip knot clip suturing method: An ex vivo feasibility study (with video). (2016)
  • Author(s): Nishizawa, T., Uraoka, T., Sagara, S., Suzuki, H., Akimoto, T., Kanai, T., Yahagi, N.
  • Journal Title: Gastrointest. Endosc. Volume: 83 Pages: 447-450
  • Peer Reviewed / Open Access
• [Journal Article] Association of baseline plasma des-acyl ghrelin level with the response to rikkunshito in patients with functional dyspepsia. (2016)
  • Author(s): Togawa, K., Matsuzaki, J., Kobayakawa, M., Fukushima, Y., Suzaki, F., Kasugai, K., Nishizawa, T., Naito, Y., Hayakawa, T., Kamiya, T., Andoh, T., Yoshida, H., Tokura, Y., Nagata, H., Mori, M., Kato, K., Hosoda, H., Takebayashi, T., Miura, S., Uemura, N., Joh, T., Hibi, T., Suzuki, H.
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 31 Issue: 2 Pages: 334-341
  • DOI: 10.1111/jgh.13074
  • Peer Reviewed / Open Access
• [Journal Article] Emerging treatments in neurogastroenterology: Acotiamade, a novel treatment option for functional dyspepsia (2016)
  • Author(s): Matsushita M., Masaoka T., Suzuki H.
  • Journal Title: Neurogastroenterol Motil. Volume: 28 Issue: 5 Pages: 631-8
  • DOI: 10.1111/nmo.12756
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of carbon dioxide insufflation in balloon-assisted enteroscopy: A systematic review and meta-analysis (2016)
  • Author(s): Nishizawa, T., Suzuki, H., Fujimoto, A., Ochiai, Y., Kanai, T., Yahagi, N.
  • Journal Title: United European Gastroenterology Journal Volume: 4 Issue: 1 Pages: 11-17
  • DOI: 10.1177/2050640615588024
  • Peer Reviewed / Open Access
• [Journal Article] Effects of preoperative proton pump inhibitor administration on bleeding after gastric endoscopic submucosal dissection: A systematic review and meta-analysis. (2016)
  • Author(s): Nishizawa, T., Suzuki, H.*, Akimoto, T., Maehata, T., Kanai, T., Morizane, T., Yahagi, N.
  • Journal Title: United European Gastroenterology Journal Volume: 4 Issue: 1 Pages: 5-10
  • DOI: 10.1177/2050640615588023
  • Peer Reviewed / Open Access
• [Journal Article] Safety and benefits of self-expandable metallic stents with chemotherapy for malignant gastric outlet obstruction. (2015)
  • Author(s): Miyabe K, Hayashi K, Nakazawa T, Sano H, Yamada T, Takada H, Naitoh I, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Kato A, Ohara H, Joh T.
  • Journal Title: Digestive Endoscopy Volume: 27 Issue: 1 Pages: 572-81
  • DOI: 10.1159/000440741
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy of 10-day and 14-day triple therapy as a third-line and fourth-line regimen for Helicobacter pylori eradication: a pilot study. (2015)
  • Author(s): Mori, H., Suzuki, H.*, Matsuzaki, J., Tsugawa, H., Fukuhara, S., Miyoshi, S., Hirata, K., Seino, T., Matsushita, M., Nishizawa, T., Masaoka, T., Kanai, T.
  • Journal Title: United European Gastroenterology Journal Volume: - Issue: 3 Pages: 380-387
  • DOI: 10.1177/2050640615618043
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Efficacy of 10-day Sitafloxacin-containing third-line rescue therapies for Helicobacter pylori strains containing the gyrA mutation (2015)
  • Author(s): Mori H., Suzuki H., Matsuzaki J., Tsugawa H., Fukuhara S., Miyoshi S., Hirata K., Seino T., Matsushita M., Masaoka T., Kanai T.
  • Journal Title: Helicobacter Volume: 27 Issue: 4 Pages: 286-94
  • DOI: 10.1111/hel.12286
  • Peer Reviewed / Open Access
• [Journal Article] First-line eradication for Helicobacter pylori-positive gastritis by esomeprazole-based triple therapy is influenced by CYP2C19 genotype. (2015)
  • Author(s): Saito Y, Serizawa H, Kato Y, Nakano M, Nakamura M, Saito H, Suzuki H, Kanai T.
  • Journal Title: World J. Gastroenterol. Volume: 21 Issue: 48 Pages: 13548-54
  • DOI: 10.3748/wjg.v21.i48.13548
  • Peer Reviewed / Open Access
• [Journal Article] BH3-only protein Bim is associated with the degree of Helicobacter pylori-induced gastritis and is localized to the mitochondria of inflammatory cells in the gastric mucosa (2015)
  • Author(s): Akazawa Y., Matsuda K., Isomoto H., Matsushima K., Kido Y., Urabe S., Yamaghchi N., Ohnita K., Takeshima F., Kondo H., Tsugawa H., Suzuki H., Moss J., Nakao K., Nakashima M.
  • Journal Title: Int. J. Med. Microbiol. Volume: 305 Issue: 6 Pages: 553-562
  • DOI: 10.1016/j.ijmm.2015.07.002
  • Peer Reviewed / Open Access
• [Journal Article] Association of Visceral Fat Area, Smoking, and Alcohol Consumption with Reflux Esophagitis and Barrett's Esophagus in Japan. (2015)
  • Author(s): Matsuzaki J, Suzuki H, Kobayakawa M, Inadomi JM, Takayama M, Makino K, Iwao Y, Sugino Y, Kanai T
  • Journal Title: PLoS One. Volume: 10 Issue: 7 Pages: 1-15
  • DOI: 10.1371/journal.pone.0133865
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] New Endoscopic Suturing Method:slip knot clip suturing. (2015)
  • Author(s): Nishizawa, T., Uraoka, T., Suzuki, H., Goto, O., Ochiai, Y., Fujimoto, A., Maehata, T., Kanai, T., Yahagi, N.
  • Journal Title: Gastrointest. Endosc. Volume: 82 Issue: 3 Pages: 570-571
  • DOI: 10.1016/j.gie.2015.04.012
  • Peer Reviewed / Open Access
• [Journal Article] Nordihydroguaiaretic acid disrupts the antioxidant ability of Helicobacter pylori through the repression of SodB activity in vitro. (2015)
  • Author(s): Tsugawa, H., Mori, H., Matsuzaki, J., Masaoka, T., Hirayama, T., Nagasawa, H., Sakakibara, Y., Suematsu, M., Suzuki, H.
  • Journal Title: Biomed. Res. Int. Volume: 2015 Pages: 734548-734548
  • DOI: 10.1155/2015/734548
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The “two-sword fencing” technique in endoscopic submucosal dissection. (2015)
  • Author(s): Nishizawa, T., Uraoka, T., Ochiai, Y., Suzuki, H., Goto, O., Fujimoto, A., Maehata, T., Kanai, T., Yahagi, N.
  • Journal Title: Clin. Endosc. Volume: 48 Issue: 1 Pages: 85-86
  • DOI: 10.5946/ce.2015.48.1.85
  • Peer Reviewed / Open Access
• [Journal Article] Survey of clinical practice for irritable bowel syndrome in East asian countries. (2015)
  • Author(s): Fukudo S, Hahm KB, Zhu Q, Sollano JD, Rani AA, Syam AF, Kachintorn U, Suzuki H, Kamiya T, Joh T, Uchiyama K, Naito Y, Takahashi S, Kinoshita Y, Ueno F, Yamagami H, Chan FK, Fock KM, Arakawa T; International Gastrointestinal Consensus Symposium Study Group.
  • Journal Title: Digestion Volume: 91 Issue: 1 Pages: 99-109
  • DOI: 10.1159/000369078
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clarithromycin versus metronidazole as first-line Helicobacter pylori eradication: A multicenter, prospective, randomized controlled study in Japan. (2015)
  • Author(s): Nishizawa, T., Maekawa, T., Watanabe, N., Harada, N., Hosoda, Y., Yoshinaga, M., Yoshio, T., Ohta, H., Inoue, S., Toyokawa, T., Yamashita, H., Saito, H., Kuwai, T., Katayama, S., Masuda, E., Miyabayashi, H., Kimura, T., Nishizawa, Y., Takahashi, M., Suzuki, H.
  • Journal Title: J. Clin. Gastroenterol. Volume: 49 Issue: 6 Pages: 468-71
  • DOI: 10.1097/mcg.0000000000000165
  • Peer Reviewed / Open Access
• [Journal Article] Timing of oral refeeding in acute pancreatitis: A systematic review and meta-analysis. (2015)
  • Author(s): Horibe, M., Nishizawa, T., Suzuki, H., Minami, K., Yahagi, N., Iwasaki, E., Kanai, K.
  • Journal Title: United European Gastroenterology Journal Volume: - Issue: 6 Pages: 725-732
  • DOI: 10.1177/2050640615612368
  • Peer Reviewed / Open Access
• [Journal Article] Helicobacter pylori: Helicobacter pylori gastritis-a novel distinct disease entity. (2015)
  • Author(s): Suzuki, H.*, Mori, H.
  • Journal Title: Nature Rev. Gastroenterol. Hepatol. Volume: 12 Issue: 10 Pages: 556-557
  • DOI: 10.1038/nrgastro.2015.158
  • Peer Reviewed / Open Access
• [Journal Article] Role of microRNAs-221/222 in digestive systems. (2015)
  • Author(s): Matsuzaki, J., Suzuki, H.
  • Journal Title: J. Clin. Med. Volume: 4 Issue: 8 Pages: 1566-1577
  • DOI: 10.3390/jcm4081566
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Editorial: Helicobacter pylori and pathogenesis. (2015)
  • Author(s): Tomoda, A., Kamiya, S., Suzuki, H.
  • Journal Title: BioMed. Res. Int. Volume: 304768 Pages: 2-2
  • DOI: 10.1155/2015/304768
  • Peer Reviewed / Open Access
• [Journal Article] Letter: Prompt endoscopy in Asians with uninvestigated dyspepsia - authors' reply. (2015)
  • Author(s): Chen, S.L., Gwee, K.A., Lee, J.S., Miwa, H., Suzuki, H., Guo, P., Hao, Y.T., Chen, M.H.
  • Journal Title: Aliment. Pharm. Ther. Volume: 41 Issue: 8 Pages: 793-793
  • DOI: 10.1111/apt.13131
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Proton pump inhibitor alone vs proton pump inhibitor plus mucosal protective agents for endoscopic submucosal dissection-induced ulcer: a systematic review and meta-analysis (2015)
  • Author(s): Nishizawa, T., Suzuki, H.*, Kanai, T., Yahagi, N.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 56 Issue: 2 Pages: 85-90
  • DOI: 10.3164/jcbn.14-101
  • NAID: 130004879373
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access
• [Journal Article] Evidence-based clinical practice guidelines for functional dyspepsia. (2015)
  • Author(s): Miwa H, Kusano M, Arisawa T, Oshima T, Kato M, Joh T, Suzuki H, Tominaga K, Nakada K, Nagahara A, Futagami S, Manabe N, Inui A, Haruma K, Higuchi K, Yakabi K, Hongo M, Uemura N, Kinoshita Y, Sugano K, Shimosegawa T
  • Journal Title: J Gastroenterol Volume: 50 Issue: 2 Pages: 125-39
  • DOI: 10.1007/s00535-014-1022-3
  • Peer Reviewed / Open Access
• [Journal Article] Reply to letter: "Dexmedetomidine vs midazolam for gastrointestinal endoscopy". (2015)
  • Author(s): Nishizawa T, Suzuki H.
  • Journal Title: Digest. Endosc. Volume: 27 Issue: 4 Pages: 533-533
  • DOI: 10.1111/den.12459
  • Peer Reviewed / Open Access
• [Journal Article] Systematic review with meta-analysis: prompt endoscopy as the initial management strategy for uninvestigated dyspepsia in Asia. (2015)
  • Author(s): Chen, S.L., Gwee, K.A., Lee, J.S., Miwa, H., Suzuki, H., Guo, P., Hao, Y.T., Chen, M.H.
  • Journal Title: Aliment. Pharm. Ther. Volume: 41 Issue: 3 Pages: 239-252
  • DOI: 10.1111/apt.13028
  • Peer Reviewed / Open Access
• [Journal Article] Gastric carcinogenesis and underlying molecular mechanisms: Helicobacter pylori and novel targeted therapy. (2015)
  • Author(s): Nishizawa, T., Suzuki, H.
  • Journal Title: Biomed. Res. Int. Volume: 2015 Pages: 794378-794378
  • DOI: 10.1155/2015/794378
  • Peer Reviewed / Open Access
• [Journal Article] Second-look endoscopy after endoscopic submucosal dissection for gastric neoplasms: A systematic review. (2015)
  • Author(s): Nishizawa, T., Suzuki, H., Kinoshita, S., Goto, O., Kanai, T., Yahagi, N.
  • Journal Title: Digest. Endosc. Volume: 27 Issue: 3 Pages: 279-284
  • DOI: 10.1111/den.12410
  • Peer Reviewed / Open Access
• [Journal Article] Dexmedetomidine versus midazolam for gastrointestinal endoscopy: A meta-analysis. (2015)
  • Author(s): Nishizawa T, Suzuki, H., Sagara S, Kanai T, Yahagi N.
  • Journal Title: Digest. Endosc. Volume: 27 Issue: 1 Pages: 8-15
  • DOI: 10.1111/den.12399
  • NAID: 130005110111
  • Peer Reviewed / Open Access
• [Journal Article] Obscure Gastrointestinal Bleeding: Resection of a Pyogenic Granuloma of the Ileum via Double-balloon Enteroscopy. (2014)
  • Author(s): Hirata, K., Hosoe, N., Imaeda, H., Naganuma, M., Murata, H., Ueno, M., Suzuki, H., Ogata, H., Kanai, T.
  • Journal Title: Clin. J. Gastroenterol. Volume: 7 Pages: 397-401
  • Peer Reviewed / Open Access
• [Journal Article] Surveillance using trimodal imaging endoscopy after endoscopic submucosal dissection for superficial gastric neoplasia. (2014)
  • Author(s): Imaeda H, Hosoe N, Kashiwagi K, Ida Y, Nakamura R, Suzuki H, Saito Y, Yahagi N, Iwao Y, Kitagawa Y, Hibi T, Ogata H, Kanai T.
  • Journal Title: World Journal of Gastroenterology Volume: 20(43) Issue: 43 Pages: 16311-7
  • DOI: 10.3748/wjg.v20.i43.16311
  • Peer Reviewed / Open Access
• [Journal Article] Musosal expression of aquaporin-4 in the stomach of histamine type 2 receptor knockout mice and Helicobacter pylori-infected mice. (2014)
  • Author(s): Fukuhara, S., Matsuzaki, J., Tsugawa, H., Masaoka, T., Miyoshi, S., Mori, H., Fukushima, Y., Yasui, M., Kanai, T., Suzuki, H.
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 29 Issue: S4 Pages: 53-59
  • DOI: 10.1111/jgh.12771
  • Peer Reviewed / Open Access
• [Journal Article] Alteration of angiogenesis in Helicobacter-heilmannii-induced MALT lymphoma: interaction with c-Met and HGF. (2014)
  • Author(s): Nakamura, M., Takahashi, T., Matsui, H., Baniwa, Y., Takahashi, S., Murayama, S.Y., Serizawa, H., Suzuki, H., Hibi, T.
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 29 Issue: S4 Pages: 70-76
  • DOI: 10.1111/jgh.12776
  • Peer Reviewed / Open Access
• [Journal Article] Clarithromycin versus metronidazole as first-line Helicobacter pylori eradication: A multicenter, prospective, randomized controlled study in Japan. (2014)
  • Author(s): Nishizawa, T., Maekawa, T., Watanabe, N., Harada, N., Hosoda, Y., Yoshinaga, M., Yoshio, T., Ohta, H., Inoue, S., Toyokawa, T., Yamashita, H., Saito, H., Kuwai, T., Katayama, S., Masuda, E., Miyabayashi, H., Kimura, T., Nishizawa, Y., Takahashi, M., Suzuki, H.
  • Journal Title: J. Clin. Gastroenterol. Volume: Epub
  • Peer Reviewed / Open Access
• [Journal Article] Randomised clinical trial : rikkunshito in the treatment of functional dyspepsia–a multi-centre, double-blind, randomised, placebo-controlled study (2014)
  • Author(s): Suzuki, H., Matsuzaki, J., Fukushima, Y., Suzaki, F., Kasugai, K., Nishizawa, T., Naito, Y., Hayakawa, T., Kamiya, T., Andoh, T., Yoshida, H., Tokura, Y., Nagata, H., Kobayakawa, M., Mori, M., Kato, K., Hosoda, H., Takabayashi, T., Miura, S., Uemura, N., Joh, T., Hibi, T., Tack, J.
  • Journal Title: Neurogastr oenterol. Motil. Volume: (Epub) Issue: 7 Pages: 950-961
  • DOI: 10.1111/nmo.12348
  • Peer Reviewed / Open Access
• [Journal Article] Control of tip deflection by right pinkie shaft grip: right pinkie maneuver. (2014)
  • Author(s): Nishizawa, T., Uraoka, T., Suzuki, H., Ochiai, Y., Goto, O., Fujimoto, A., Maehata, T., Kanai, T., Yahagi, N.
  • Journal Title: Gastrointest. Endosc. Volume: 80 Issue: 6 Pages: 1208-1208
  • DOI: 10.1016/j.gie.2014.08.016
  • Peer Reviewed / Open Access
• [Journal Article] Control of the treatment device for endoscope by left hand: two fingers method. (2014)
  • Author(s): Nishizawa, T., Uraoka, T., Suzuki, H., Kinoshita, S., Ochiai, Y., Goto, O., Fujimoto, A., Kanai, T., Yahagi, N.
  • Journal Title: Gastrointest. Endosc. Volume: 80 Issue: 6 Pages: 1206-1207
  • DOI: 10.1016/j.gie.2014.07.063
  • Peer Reviewed / Open Access
• [Journal Article] Greater loss of productivity among Japanese workers with gastroesophageal reflux disease (GERD) symptoms that persist vs resolve on medical therapy. (2014)
  • Author(s): Suzuki, H., Matsuzaki, J., Masaoka, T., Inadomi, J.M.
  • Journal Title: Neurogastroenterol. Motil. Volume: - Issue: 6 Pages: 764-771
  • DOI: 10.1111/nmo.12319
  • Peer Reviewed / Open Access
• [Journal Article] Ameliorative effect of mepenzolate bromide against pulmonary fibrosis. (2014)
  • Author(s): Kurotsu, S., Tanaka, K., Niino, T., Asano, T., Sugizaki, T., Azuma, A., Suzuki, H., Mizushima, T.
  • Journal Title: J. Pharmacol. Exp. Ther. Volume: 350 Issue: 1 Pages: 79-88
  • DOI: 10.1124/jpet.114.213009
  • Peer Reviewed / Open Access
• [Journal Article] Superiority of pulmonary administration of mepenzolate bromide over of her routes as treatment for chronic obstructive pulmonary disease (2014)
  • Author(s): Tanaka K., et al.
  • Journal Title: Sci Rep. Volume: 4 Issue: 1 Pages: 1-11
  • DOI: 10.1038/srep04510
  • Peer Reviewed / Open Access
• [Journal Article] A questionnaire-based survey on the diagnosis and management of inflammatory bowel disease in East Asian countries in 2012. (2014)
  • Author(s): Hida, N., Nakamura, S., Hahm, K-B., Sollano, J.D., Zhu, Q., Rani, A.A., Syam, A.F., Kachintorn, U., Ueno, F., Joh, T., Naito, Y., Suzuki, H., Takahashi, S., Fukudo, S., Fujiwara, Y., Kinoshita, Y., Uchiyama, K., Yamaguchi, Y., Yoshida, A., Arakawa, T., Matsumoto, T., The IGICS Study Group.
  • Journal Title: Digestion Volume: 89(1) Issue: 1 Pages: 88-103
  • DOI: 10.1159/000356706
  • Peer Reviewed / Open Access
• [Journal Article] New pharmaceutical treatment of gastric MALT lymphoma: anti-angiogenesis treatment using VEGF receptor antibodies and celecoxib. (2014)
  • Author(s): Nakamura, M., Takahashi, T., Matsui, H., Takahashi, S., Murayama, SY., Suzuki, H., Tsuchimoto, K.
  • Journal Title: Curr. Pharm. Des. Volume: 20 Pages: 1097-1103
  • Peer Reviewed / Open Access
• [Journal Article] Effect of supplementation with rebamipide for Helicobacter pylori eradication therapy: a systematic review and meta-analysis. (2014)
  • Author(s): Nishizawa, T., Nishizawa, Y., Yahagi, N., Kanai, T., Takahashi, M., Suzuki, H.
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 29 Issue: S4 Pages: 20-24
  • DOI: 10.1111/jgh.12769
  • Peer Reviewed / Open Access
• [Journal Article] Mechanisms of Helicobacter pylori antibiotic resistance and molecular testing. (2014)
  • Author(s): Nishizawa, T., Suzuki, H.
  • Journal Title: Front. Mol. Biosci. Volume: 1 Pages: 19-19
  • DOI: 10.3389/fmolb.2014.00019
  • Peer Reviewed / Open Access
• [Journal Article] Propofol vs traditional sedative agents for endoscopic submucosal dissection: A systematic review. (2014)
  • Author(s): Nishizawa, T., Suzuki, H., Matsuzaki, J., Kanai, T., Yahagi, N.
  • Journal Title: Digest. Endosc. Volume: 26 Issue: 6 Pages: 701-706
  • DOI: 10.1111/den.12342
  • Peer Reviewed / Open Access
• [Journal Article] Does the AIMS65, a new risk score for upper gastrointestinal bleeding, work in Japan? (2014)
  • Author(s): Masaoka, T., Suzuki, H.
  • Journal Title: Digest. Endosc. Volume: 26 Issue: 3 Pages: 331-332
  • DOI: 10.1111/den.12224
  • Peer Reviewed / Open Access
• [Journal Article] Does bile reflux influence the progression of Barrett's esophagus to adenocarcinoma? (2014)
  • Author(s): Masaoka, T., Suzuki, H.
  • Journal Title: J. Neurogastroenterol. Motil. Volume: 20(1) Issue: 1 Pages: 124-126
  • DOI: 10.5056/jnm.2014.20.1.124
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNAs in Barrett’s esophagus: Future prospects. (2014)
  • Author(s): Matsuzaki, J., Suzuki, H.
  • Journal Title: Front. Genet. Volume: 5 Pages: 69-69
  • DOI: 10.3389/fgene.2014.00069
  • Peer Reviewed / Open Access
• [Journal Article] World’s first telepathology experiments employing ultra-high-speed internet satellite, nickenemaed “KIZUNA”. (2013)
  • Author(s): Sawai T, Uzuki M, Miura Y, Kamataki A, Matsumura T, Saito K, Kurose A, Osamura YR, Yoshimi N, Kanno H, Moriya T, Ishida Y, Satoh Y, Nakao M, Ogawa E, Matsuo S, Kasai H, Kumagai K, Motoda T, Hopson N
  • Journal Title: J Pathol Inform Volume: 4 Issue: 1 Pages: 24-24
  • DOI: 10.4103/2153-3539.119002
  • Peer Reviewed / Open Access
• [Presentation] 胃発がんに関わるピロリ菌感染宿主細胞のオートファジー発現調節機構 (2016)
  • Author(s): 津川仁、森英毅、三好佐和子、柏崎有紀、松崎潤太郎、佐藤聡、井本正哉、末松誠、鈴木秀和
  • Organizer: 第88回日本胃癌学会総会
  • Place of Presentation: 別府国際コンベンションセンター（大分県別府市）
  • Year and Date: 2016-03-19
• [Presentation] Repression of autophagy in gastric epithelial cells infected with H. pylori induces CD44 expression through the accumulation of CagA oncoprotein. (2015)
  • Author(s): Tsugawa H., Kashiwazaki Y., Mori H., Matsuzaki J., Masaoka T., Suematsu M., Suzuki H.
  • Organizer: 10th World Congress for Microcirculation
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2015-09-25
  • Int'l Joint Research
• [Presentation] CD44発現に繋がるピロリ菌感染宿主細胞キャラクター (2015)
  • Author(s): 津川仁、柏崎有紀、森英毅、松崎潤太郎、佐藤聡、金井弥栄、井本正哉、末松誠、鈴木秀和
  • Organizer: 第21回日本ヘリコバクター学会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県神戸市）
  • Year and Date: 2015-06-26
• [Presentation] LRP1-dependent host cell response in gastric epithelial cells infected with H. pylori (2015)
  • Author(s): 津川 仁、松崎 潤太郎、森 英毅、正岡 建洋、井本 正哉、末松 誠、鈴木 秀和
  • Organizer: 第88回日本細菌学会総会
  • Place of Presentation: 長良川国際会議場（岐阜県岐阜市）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] Major publications in FGID and Neurogastroenterology from the West. (2015)
  • Author(s): Suzuki, H.
  • Organizer: The 4th Biennial Congress of the Asian Neurogastroenterology and Motility Association (ANMA)
  • Place of Presentation: Gurgaon, Delhi, India
  • Year and Date: 2015-02-08
  • Invited
• [Presentation] HER2陽性胃癌における酸化ストレス抵抗性がん幹細胞によるTrastuzumab耐性の獲得機構 (2014)
  • Author(s): 森英毅、津川仁、鈴木秀和
  • Organizer: JDDW 2014 （日本消化器病関連学会週間）
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2014-10-23
• [Presentation] Nuclear-translocated LRP1-ICD is related to the formation of autophagolysosome associated with CagA degradation in gastric epithelial cells infected with H. pylori via induction of LAMP1 expressions. (2014)
  • Author(s): Tsugawa H., Matsuzaki J., Mori H., Masaoka T., Sato A., Imoto M., Hirayama T., Suematsu M., Suzuki H.
  • Organizer: XXVIIth International Workshop on Helicobacter & Microbiota in Inflammation & Cancer
  • Place of Presentation: Rome, Italy
  • Year and Date: 2014-09-12
• [Presentation] 胃食道逆流症(GERD)－病態・症状、診断、労働生産性から. (2014)
  • Author(s): 鈴木秀和
  • Organizer: 第56回日本平滑筋学会総会
  • Place of Presentation: 新横浜プリンスホテル（神奈川県横浜市）
  • Year and Date: 2014-08-07
  • Invited
• [Presentation] 生まれ変わる慢性胃炎の診療法～ガイドラインに基づく診療法について～ (2014)
  • Author(s): 鈴木秀和
  • Organizer: 第87回日本消化器内視鏡学会総会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2014-05-16
  • Invited
• [Presentation] Efficacy and safety of rikkunshito, a Japanese herbal medicine, on the treatment of functional dyspepsia: a multi-center, double-blind, randomized, placebo-controlled study. (2014)
  • Author(s): Suzuki, H., Matsuzaki, J., Fukushima, Y., Suzaki, F., Kasugai, K., Nishizawa, T., Naito, Y., Hayakawa, T., Kamiya, T., Ando, T., Yoshida, H., Tokura, Y., Nagata, H., Kobayakawa, M., Mori, M., Kato, K., Hosoda, H., Takebayashi, T., Miura, S., Uemura, N., Joh, T., Hibi, T., Tack, J.
  • Organizer: Digestive Disease Week 2014
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2014-05-03
• [Presentation] 機能性ディスペプシア（FD）に対する六君子湯の有効性（多施設共同二重盲検無作為化プラセボ対照比較試験) (2014)
  • Author(s): 鈴木秀和、松崎潤太郎、福嶋康之
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2014-04-23
• [Book] Helicobacter (2016)
  • Author(s): Hidekazu Suzuki, Robin Warren, Barry Marshall, eds.
  • Total Pages: 267
  • Publisher: Springer Japan
• [Book] eBook: OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS (2014)
  • Author(s): Suzuki, H., Nishizawa, T.
  • Publisher: Academic Press
• [Patent(Industrial Property Rights)] 宿主異物排除応答依存的除菌剤 (2015)
  • Inventor(s): 鈴木秀和、津川仁、榊原康文
  • Industrial Property Rights Holder: 鈴木秀和、津川仁、榊原康文
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-05-22
• [Patent(Industrial Property Rights)] 宿主異物排除応答依存的除菌剤 (2014)
  • Inventor(s): 鈴木秀和、津川仁、榊原康文
  • Industrial Property Rights Holder: 鈴木秀和、津川仁、榊原康文
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-05-22