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Indole analog mitochonic acid-5 (MA-5) has novel therapeutic effects on kidney injury

Research Project

Project/Area Number 26670070
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionTohoku University

Principal Investigator

ABE Takaaki  東北大学, 医工学研究科, 教授 (80292209)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsCKD / インドール / MA=5 / 虚血再灌流 / MA-5 / ミトコンドリア病 / 虚血 / 腎不全 / エリスロポエチン
Outline of Final Research Achievements

Chronic kidney disease (CKD) is a global health problem that carries a substantial risk for cardiovascular disease and death.
We recently found that several indole-derivatives increased ATP levels in cells by screening of 41 newly synthesized indole derivatives. Among those compounds, we focused on the most potent indole derivative #5 (Mitochonic acid 5;MA-5) (Suzuki T et al. Tohoku journal Exp Med ;236:225-232:2015). The aim of this study was to clarify the effects of MA-5 in kidney injury to prevent CKD.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2015 2014

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 6 results) Presentation (1 results)

  • [Journal Article] Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases2015

    • Author(s)
      Suzuki T, Yamaguchi H, Kikusato M, Matsuhashi T, Matsuo A, Sato T, Oba Y, Watanabe S, Minaki D, Saigusa D, Shimbo H, Mori N, Mishima E, Shima H, Akiyama Y, Takeuchi Y, Yuri A, Kikuchi K, Toyohara T, Suzuki C, Kohzuki M, Anzai J, Mano N, Kure S, Yanagisawa T, Tomioka Y, Toyomizu M, Ito S, Osaka H, Hayashi K, Abe T
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 236 Issue: 3 Pages: 225-232

    • DOI

      10.1620/tjem.236.225

    • NAID

      130005083526

    • ISSN
      0040-8727, 1349-3329
    • URL

      https://pure.teikyo.jp/en/publications/f34848a7-3f52-481e-850d-fae28c8f317e

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage.2015

    • Author(s)
      Suzuki T
    • Journal Title

      J Am Soc Nephrol.

      Volume: 26 Pages: 1-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Alteration of the Intestinal Environment by Lubiprostone Is Associated with Amelioration of Adenine-Induced CKD.2015

    • Author(s)
      Mishima E.
    • Journal Title

      J Am Soc Nephrol. 2014 Dec 18.

      Volume: 27 Pages: 271-279

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Exonic Mutations in the SLC12A3 Gene Cause Exon Skipping and Premature Termination in Gitelman Syndrome2015

    • Author(s)
      竹内陽一、三島英換、他12名
    • Journal Title

      J Am Soc Nephrol

      Volume: 26 Issue: 2 Pages: 271-279

    • DOI

      10.1681/asn.2013091013

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Kidney and Uremic Toxin Removal: Glomerulus or Tubule?2014

    • Author(s)
      Masereeuw R
    • Journal Title

      Semin Nephrol.

      Volume: 34 Issue: 2 Pages: 191-208

    • DOI

      10.1016/j.semnephrol.2014.02.010

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Organic anion transporting polypeptides 1B1 and 1B3 play an important role in uremic toxin handling and drug-uremic toxin interactions in the liver.2014

    • Author(s)
      Sato T.
    • Journal Title

      J Pharm Pharm Sci.

      Volume: 17 Pages: 475-484

    • Related Report
      2014 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] Proteomics and Metabolomics as Tools to Unravel Novel Culprits and Mechanisms of Uremic Toxicity: Instrument or Hype?2014

    • Author(s)
      Mullen W.
    • Journal Title

      Semin Nephrol.

      Volume: 34 Issue: 4 Pages: 180-190

    • DOI

      10.4103/0974-2077.150732

    • Related Report
      2014 Research-status Report
    • Acknowledgement Compliant
  • [Presentation] エリスロポエチン産生増強化合物の作用機序の解明2014

    • Author(s)
      大庭悠貴
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-07-06
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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