Indole analog mitochonic acid-5 (MA-5) has novel therapeutic effects on kidney injury
| Project/Area Number |
26670070
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
ABE Takaaki 東北大学, 医工学研究科, 教授 (80292209)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | CKD / インドール / MA=5 / 虚血再灌流 / MA-5 / ミトコンドリア病 / 虚血 / 腎不全 / エリスロポエチン |
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| Outline of Final Research Achievements |
Chronic kidney disease (CKD) is a global health problem that carries a substantial risk for cardiovascular disease and death.
We recently found that several indole-derivatives increased ATP levels in cells by screening of 41 newly synthesized indole derivatives. Among those compounds, we focused on the most potent indole derivative #5 (Mitochonic acid 5；MA-5) (Suzuki T et al. Tohoku journal Exp Med ;236:225-232:2015). The aim of this study was to clarify the effects of MA-5 in kidney injury to prevent CKD.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases2015
Author(s)
Suzuki T, Yamaguchi H, Kikusato M, Matsuhashi T, Matsuo A, Sato T, Oba Y, Watanabe S, Minaki D, Saigusa D, Shimbo H, Mori N, Mishima E, Shima H, Akiyama Y, Takeuchi Y, Yuri A, Kikuchi K, Toyohara T, Suzuki C, Kohzuki M, Anzai J, Mano N, Kure S, Yanagisawa T, Tomioka Y, Toyomizu M, Ito S, Osaka H, Hayashi K, Abe T
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Journal Title
The Tohoku Journal of Experimental Medicine
Volume: 236
Issue: 3
Pages: 225-232
DOI
NAID
ISSN
0040-8727, 1349-3329
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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