• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a novel pharmacotherapy using microneedle technology for immunologic skin diseases

Research Project

Project/Area Number 26670076
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionOsaka University

Principal Investigator

OKADA NAOKI  大阪大学, 薬学研究科(研究院), 准教授 (90312123)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsマイクロニードル / 経皮薬物治療
Outline of Final Research Achievements

Pigmented lesions such as of seborrheic keratosis and senile lentigo, which are commonly seen on skin of people>50 years of age, are considered unattractive and disfiguring because of their negative psychological impact. Drug therapy using all-trans retinoic acid (ATRA) is an attractive option for self-treatment at home. We developed an ATRA-loaded microneedle patch (ATRA-MN) and confirmed the pharmacological effects of ATRA-MN application in mice. Moreover, we conducted a clinical study to evaluate the safety and efficacy of ATRA-MN in subjects with seborrheic keratosis or senile lentigo. Desquamation of the stratum corneum was observed following four ATRA-MN applications at 1-week intervals, but ATRA-MN applications did not induce severe local or systemic adverse effects. These results showed that ATRA-MN treatment is promising as a safe and effective therapy for seborrheic keratosis and senile lentigo.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Clinical study of a retinoic acid-loaded microneedle patch for seborrheic keratosis or senile lentigo2016

    • Author(s)
      Sachiko Hirobe, Risa Otsuka, Hiroshi Iioka, Ying-Shu Quan, Fumio Kamiyama, Hideo Asada, Naoki Okada, and Shinsaku Nakagawa
    • Journal Title

      Life Sci.

      Volume: in press Pages: 24-27

    • DOI

      10.1016/j.lfs.2015.12.051

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 生体適合性材料を用いた新規ソリッドマイクロニードルパッチの開発2016

    • Author(s)
      廣部祥子, 小野彰彦, 権 英淑, 神山文男, 中川晋作, 岡田直貴
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] レーザーイオン化イメージング質量分析による経皮投与型薬剤の動態分析2015

    • Author(s)
      井本英志, 間 久直, 廣部祥子, 岡田直貴, 中川晋作, 粟津邦男
    • Organizer
      光・量子デバイス研究会
    • Place of Presentation
      東北大学東京分室 (東京都千代田区)
    • Year and Date
      2015-09-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 経皮投与型薬剤の動態分析に向けたレーザーイオン化イメージング質量分析手法の開発2015

    • Author(s)
      井本英志, 間 久直, 廣部祥子, 岡田直貴, 中川晋作, 粟津邦男
    • Organizer
      第63回質量分析総合討論会
    • Place of Presentation
      つくば国際会議場 (茨城県つくば市)
    • Year and Date
      2015-06-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] MALDI-imaging mass spectrometry for pharmacokinetics of transcutaneous medicine2015

    • Author(s)
      Eishi Imoto, Hisanao Hazama, Sachiko Hirobe, Naoki Okada, Shinsaku Nakagawa, Kunio Awazu
    • Organizer
      63rd ASMS Conference on Mass Spectrometry and Allied Topics
    • Place of Presentation
      America's Center Convention Complex (St. Louis, Missouri, U.S.A.)
    • Year and Date
      2015-05-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マイクロニードルの穿刺に伴う皮膚内免疫反応に関する基礎的検討2014

    • Author(s)
      須佐井 亮, 大塚梨沙, 廣部祥子, 権 英淑, 神山文男, 岡田直貴, 中川晋作
    • Organizer
      第30回日本DDS学会学術集会
    • Place of Presentation
      慶應義塾大学芝共立キャンパス (東京都港区)
    • Year and Date
      2014-07-30 – 2014-07-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 皮膚組織内の薬剤分析に向けたレーザーイオン化イメージング質量分析手法の開発2014

    • Author(s)
      井本英志, 間 久直, 廣部祥子, 岡田直貴, 中川晋作, 粟津邦男
    • Organizer
      第62回質量分析総合討論会
    • Place of Presentation
      ホテル阪急エキスポパーク (大阪府吹田市)
    • Year and Date
      2014-05-14 – 2014-05-16
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi