Immunosuppression of anticancer agents containing PEGylated liposomes for liver transplantation.
Project/Area Number |
26670079
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
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Research Institution | The University of Tokushima |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 血液型不適合肝移植 / 抗血液型抗体 / PEG修飾リポソーム / 抗がん剤 / DDS / 移植拒絶 / 免疫制御 / PEG修飾リポソーム |
Outline of Final Research Achievements |
We have studied the issue of if a spontaneous tolerance of B cells responding to blood group antigens frequently could be induced in ABO-incompatible pediatric liver transplantation by intraperitoneal injection of anticancer agent containing PEGylated liposomes. Here, we evaluated the role of peritoneal B-1 cells in the induction of blood group antigen (BGA)-reactive IgM in mice. We found that peritoneal B-1 cells bound to and then took up PEGylated liposomes i.p. injected. The surface modification of PEGylated liposomes with BGA further induced the uptake of PEGylated liposomes by peritoneal B-1 cells. However, unfortunately, the intraperitoneal injection of BGA modified PEGylated liposomes containing anticancer agent failed to tolerance of B cells responding to ABO-blood group antigens in LT.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Comprehensive analysis of PEGylated liposome-asscociated proteins relating to the accelerated blood clearance phenomenon by combination with shotgun analysis and conventional methods.2015
Author(s)
Kawanishi, M., Hashimoto, Y., Shimizu, T., Sagawa, I., Ishida, T., Kiwada, H.
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Journal Title
Biotech. Appl. Biochem.
Volume: 62
Issue: 4
Pages: 547-555
DOI
Related Report
Peer Reviewed
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