| Project/Area Number |
26670079
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 血液型不適合肝移植 / 抗血液型抗体 / PEG修飾リポソーム / 抗がん剤 / ＤＤＳ / 移植拒絶 / 免疫制御 / ＰＥＧ修飾リポソーム |
|---|
| Outline of Final Research Achievements |
We have studied the issue of if a spontaneous tolerance of B cells responding to blood group antigens frequently could be induced in ABO-incompatible pediatric liver transplantation by intraperitoneal injection of anticancer agent containing PEGylated liposomes. Here, we evaluated the role of peritoneal B-1 cells in the induction of blood group antigen (BGA)-reactive IgM in mice. We found that peritoneal B-1 cells bound to and then took up PEGylated liposomes i.p. injected. The surface modification of PEGylated liposomes with BGA further induced the uptake of PEGylated liposomes by peritoneal B-1 cells. However, unfortunately, the intraperitoneal injection of BGA modified PEGylated liposomes containing anticancer agent failed to tolerance of B cells responding to ABO-blood group antigens in LT.
|
