The analysis of regulation mechanisms of astrocyte migration by Bone Morphogenetic Protein inhibitor
| Project/Area Number |
26670090
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宝田 美佳 金沢大学, 医学系, 助教 (40565412)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 骨形成因子阻害因子 / アストロサイト / 脳梗塞 / グリア瘢痕 / エンドサイトーシス / BMP阻害因子 / Rab5 |
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| Outline of Final Research Achievements |
Astrocytes start to divide in the subventricular zone at the brain injury and promptly move to the damaged area. However, the mechanism of migration to the region is not well understood. We found one of BMP inhibitor is a strong repellent to the astrocytes. Strong assay using BMP inhibitor showed the avoidance of astrocyte A1 cells to the protein. In addition, the BMP inhibitor was incorporated into the early endosome and late endosome, indicating the novel mechanisms. Furthermore, three days after the middle cerebral artery occlusion, the factor was highly upregulated in the infarct region where astrocyte did not invade, and was secreted from NG2 positive microglia.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Ion channels, guidance molecules, intracellular signaling and transcription factors regulating nervous and vascular system development.2015
Author(s)
Akita, T., Kumada, T., Yoshihara, S. I., Egea, J., and Yamagishi, S.
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Journal Title
J Physiol Sci.
Volume: 66
Issue: 2
Pages: 175-188
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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