| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Circadian clocks constitute ubiquitous processes that regulate various biochemical and physiological events occurring with a 24 hour periodicity. Zebrafish eggs are fertilized externally and embryos develop rapidly from fertilized eggs to larvae that swim, making them an excellent model for studies of vertebrate circadian clocks’ establish. Previous studies have reported that circadian rhythms in clock-controlled genes’ expression and locomotor activity in zebrafish larvae are not observed when zebrafish are raised in constant conditions. These rhythms emerge only if embryos are exposed to environmental signals such as light. However the molecular mechanisms underlying how these circadian rhythms are set in motion during development remains unclear. This study used chemical library and have identified the signaling pathways and transcription factors, which are involved in establishment of circadian clock during development.
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