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Can skeletal muscle be a therapeutic target for treatment of autonomic dysfunction in heart failure?

Research Project

Project/Area Number 26670112
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionTottori University

Principal Investigator

Koba Satoshi  鳥取大学, 医学部, 准教授 (40565743)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords心不全 / 自律神経 / 骨格筋 / 酸化ストレス / 交感神経 / 活動筋反射 / 交感神経活動
Outline of Final Research Achievements

We attempted to quantitatively examine the relationship between activation of skeletal muscle and sympathetic nerves under the conscious state. We only succeeded in measuring either sympathetic nerve activity or electromyogram in conscious rats because of noise artifacts inevitable when simultaneously measured. In the experiment with measurements of rat arterial pressure and heart rate, intravenous infusion of Tempol, an antioxidant chemical, did not have effects to modulate cardiovascular responses in association with freezing behavior in rats. This observation suggested that central, rather than peripheral, factors played a dominant role in producing excessive sympathoexcitation seen in association with freezing behavior in conscious rats with heart failure. The data did not support the hypothesis that skeletal muscle can be a therapeutic target for treatment of autonomic dysfunction in heart failure.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (9 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Exercise pressor reflex in health and diseases: Animal studies2015

    • Author(s)
      Satoshi Koba
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 4 Issue: 2 Pages: 151-160

    • DOI

      10.7600/jpfsm.4.151

    • NAID

      130005073626

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ホワイトノイズ音曝露によって発現上昇するラット脳内Fosタンパク質の観察2015

    • Author(s)
      井上崚、木場智史、渡邊達生
    • Journal Title

      米子医学雑誌

      Volume: 66(2/3) Pages: 47-51

    • NAID

      120005614452

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Exercise pressor reflex in health and diseases: animal studies2015

    • Author(s)
      Koba S
    • Journal Title

      Journal of Physical Fitness and Sports Medicine

      Volume: in press

    • NAID

      130005073626

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Central command dysfunction in rats with heart failure is mediated by brain oxidative stress and normalised by exercise training.2014

    • Author(s)
      Koba, S., Hisatome, I. and Watanabe, T.
    • Journal Title

      Journal of Physiology (London)

      Volume: 592 Issue: 17 Pages: 3917-3931

    • DOI

      10.1113/jphysiol.2014.272377

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 心不全における運動時交感神経調節の異常と酸化ストレス2016

    • Author(s)
      Satoshi Koba
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Caudal lateral/ventrolateral periaqueductal gray projects to the rostral ventrolateral medulla in rats2016

    • Author(s)
      Momone Kato, Satoshi Koba, Ryo Inoue, Tatsuo Watanabe
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Does voluntary exercise uniformly increase Fos protein expression within paraventricular hypothalamic nucleus subdivisions in rats?2016

    • Author(s)
      Eri Hanai, Satoshi Koba, Tatsuo Watanabe
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] セントラルコマンド:運動時の循環系の中枢制御2015

    • Author(s)
      木場智史
    • Organizer
      第68回日本自律神経学会大会
    • Place of Presentation
      ウインクあいち(名古屋市)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Central command regulation of sympathetic nerve activity in health and heart failure2015

    • Author(s)
      Satoshi Koba
    • Organizer
      The 11th WORLD CONGRESS of the International Society for ADAPTIVE MEDICINE
    • Place of Presentation
      米子コンベンションセンター(米子市)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] c-Fos expression in rat periaqueductal gray induced by white noise sound exposure2015

    • Author(s)
      Koba S, Inoue R, Watanabe T
    • Organizer
      Experimental Biology 2015
    • Place of Presentation
      米国ボストン
    • Year and Date
      2015-03-28 – 2015-04-01
    • Related Report
      2014 Research-status Report
  • [Presentation] Oxidative stress in the lateral/ventrolateral periaqueductal gray does not play a role in evoking abnormal fear bradycardia2015

    • Author(s)
      Koba S, Hisatome I, Watanabe T
    • Organizer
      第 92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] ホワイトノイズ音曝露時のラット心拍数調節における中脳中心灰白質の役割2014

    • Author(s)
      木場智史、井上崚、渡邊達生
    • Organizer
      第66回日本生理学会中国・四国地方会
    • Place of Presentation
      情報通信交流館 e-とぴあ・かがわ(高松市)
    • Year and Date
      2014-11-01 – 2014-11-02
    • Related Report
      2014 Research-status Report
  • [Presentation] Fear induced bradycardia is abnormal in rats with heart failure2014

    • Author(s)
      Koba S, Hisatome I, Watanabe T
    • Organizer
      Experimental Biology 2014
    • Place of Presentation
      米国サンディエゴ
    • Year and Date
      2014-04-26 – 2014-04-30
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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