Can skeletal muscle be a therapeutic target for treatment of autonomic dysfunction in heart failure?
| Project/Area Number |
26670112
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Tottori University |
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Principal Investigator |
Koba Satoshi 鳥取大学, 医学部, 准教授 (40565743)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 心不全 / 自律神経 / 骨格筋 / 酸化ストレス / 交感神経 / 活動筋反射 / 交感神経活動 |
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| Outline of Final Research Achievements |
We attempted to quantitatively examine the relationship between activation of skeletal muscle and sympathetic nerves under the conscious state. Ｗe only succeeded in measuring either sympathetic nerve activity or electromyogram in conscious rats because of noise artifacts inevitable when simultaneously measured. In the experiment with measurements of rat arterial pressure and heart rate, intravenous infusion of Tempol, an antioxidant chemical, did not have effects to modulate cardiovascular responses in association with freezing behavior in rats. This observation suggested that central, rather than peripheral, factors played a dominant role in producing excessive sympathoexcitation seen in association with freezing behavior in conscious rats with heart failure. The data did not support the hypothesis that skeletal muscle can be a therapeutic target for treatment of autonomic dysfunction in heart failure.
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Report
(3 results)
Research Products
(13 results)
