Profiling of Central Arterial Hemodynamics for Cerebrovscular Disease Prevention
| Project/Area Number |
26670116
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
Sugawara Jun 国立研究開発法人産業技術総合研究所, 人間情報研究部門, 主任研究員 (00357261)
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| Co-Investigator(Renkei-kenkyūsha) |
MAEDA Seiji 筑波大学, 体育系, 教授 (30282346)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脳血管疾患 / 加齢 / 動脈伸展性 / 有酸素性持久力 / 周波数解析 / 動脈スティフネス |
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| Outline of Final Research Achievements |
From the standpoint of cerebrovascular diseases prevention, we sought useful assessment for pulsatility of cerebral hemodynamics by frequency-domain analysis in 14 healthy young men (Study 1), and elucidate physiological mechanisms responsible for carotid arterial distensibility in healthy men with wide age-range (18-64 yrs) (Study 2). In Study 1, pulsatile component of transfer function gain (between pulsatile aortic pressure and pulsatile cerebral blood flow velocity) was significantly enhanced by -30 mmHg of lower-body negative pressure, suggesting that moderate sympathetic nervous stimulation can manipulate pulsatile component of hemodynamic transmission. Results of Study 2 show that greater gradient of blood flow velocity during a cardiac cycle are favorably associated with distensibility of carotid artery, and that greater gradient of blood flow velocity is associated with higher aerobic capacity (e.g., maximal oxygen consumption).
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Report
(3 results)
Research Products
(9 results)
