| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Nodes of Ranvier play a pivotal role in fast transmission of sensory- and motor information in the peripheral nervous system, and disruption of nodes of Ranvier can be a cause of various neurological diseases. To gain the insight into how disruption of nodes of Ranvier occurs during the disease progression, we aimed to develop a method that allows analysis of nodes of Ranvier dynamics in the intact tissue. We developed a fluorescent probe that labels nodes of Ranvier. By expressing this probe in mice spinal cord using AAV vector, we analyzed the morphological changes nodes of Ranvier in diseased nerves.
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