Imaging-based analysis of nodes of Ranvier dynamics
Project/Area Number |
26670120
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
General pharmacology
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Research Institution | Institute of Physical and Chemical Research (2015) The University of Tokyo (2014) |
Principal Investigator |
Ino Daisuke 国立研究開発法人理化学研究所, 生命システム研究センター, 特別研究員 (40721981)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 有髄神経 / Ranvier絞輪 / イメージング / 軸索 |
Outline of Final Research Achievements |
Nodes of Ranvier play a pivotal role in fast transmission of sensory- and motor information in the peripheral nervous system, and disruption of nodes of Ranvier can be a cause of various neurological diseases. To gain the insight into how disruption of nodes of Ranvier occurs during the disease progression, we aimed to develop a method that allows analysis of nodes of Ranvier dynamics in the intact tissue. We developed a fluorescent probe that labels nodes of Ranvier. By expressing this probe in mice spinal cord using AAV vector, we analyzed the morphological changes nodes of Ranvier in diseased nerves.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Neuronal regulation of Schwann cell mitochondrial Ca2+ Signaling during myelination.2015
Author(s)
Ino, D., Sagara, H., Suzuki, J., Kanemaru, K., Okubo, Y., and *Iino, M.
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Journal Title
Cell Rep.
Volume: 12
Issue: 12
Pages: 1951-1959
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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