A research on the effects of miRNAs on serotonergic neuronal functions

• Project/Area Number: 26670122
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: Osaka University
• Principal Investigator: Hashimoto Hitoshi 大阪大学, 薬学研究科, 教授 (30240849)
• Research Collaborator: NAGAYASU Kazuki 京都大学, 大学院薬学研究科, 助教 (00717902)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: セロトニン / miRNA / 幹細胞 / 国際情報交換（アメリカ合衆国）

Outline of Final Research Achievements

The understanding of biological mechanisms for psychiatric disorders is important for the development of new therapeutic strategy. Here we focused on the miRNAs highly expressed in serotonergic neurons, one of the most important neurons in mood regulation and hallucination. As a result, we found that (1) in immature brain, a certain miRNA affects the expression level of transcription factors important for normal development of serotonergic neurons and a certain type of serotonin receptor and that (2) in mature brain, a certain miRNA affects the expression level of transcription factors important for normal function of serotonergic neurons and serotonin metabolism.

Research Products

• [Journal Article] Decreased cohesion in the brain leads to defective synapse development and anxiety-related behavior (2017)
  • Author(s): Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T.
  • Journal Title: J. Exp. Med. Volume: 印刷中 Issue: 5 Pages: 1431-1452
  • DOI: 10.1084/jem.20161517
  • Peer Reviewed / Open Access
• [Journal Article] Early Neurobehavioral Development of Mice Lacking Endogenous PACAP (2017)
  • Author(s): Farkas J, Sandor B, Tamas A, Kiss P, Hashimoto H, Nagy AD, Fulop BD, Juhasz T, Manavalan S, Reglodi D.
  • Journal Title: J. Mol. Neurosci. Volume: 61(4) Issue: 4 Pages: 468-478
  • DOI: 10.1007/s12031-017-0887-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia. (2017)
  • Author(s): Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, Ohmori T.
  • Journal Title: Int J Mol Sci. Volume: 18 Issue: 3 Pages: 632-632
  • DOI: 10.3390/ijms18030632
  • NAID: 120006535029
  • Peer Reviewed / Open Access
• [Journal Article] Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. (2017)
  • Author(s): Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R.
  • Journal Title: Schizophr Res. Volume: 181 Pages: 75-82
  • DOI: 10.1016/j.schres.2016.10.012
  • NAID: 120007037467
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Role of prefrontal serotonergic and dopaminergic systems in encounter-induced hyperactivity in methamphetamine-sensitized mice (2016)
  • Author(s): Tanaka T, Ago Y, Umehara C, Imoto E, Hasebe S, Hashimoto H, Takuma K, Matsuda T.
  • Journal Title: Int. J. Neuropsychopharmacol. Volume: 20 Pages: 410-420
  • DOI: 10.1093/ijnp/pyw115
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Critical involvement of the orbitofrontal cortex in hyperlocomotion induced by NMDA receptor blockade in mice. (2016)
  • Author(s): Seiriki K, Kasai A, Kuwaki T, Nakazawa T, Yamaguchi S, Hashimoto H.
  • Journal Title: Biochem Biophys Res Commun. Volume: 480 Issue: 4 Pages: 558-563
  • DOI: 10.1016/j.bbrc.2016.10.089
  • Peer Reviewed / Open Access
• [Journal Article] Double In situ Hybridization for MicroRNAs and mRNAs in Brain Tissues. (2016)
  • Author(s): Kasai A, Kakihara S, Miura H, Okada R, Hayata-Takano A, Hazama K, Niu M, Shintani N, Nakazawa T, Hashimoto H.
  • Journal Title: Front Mol Neurosci. Volume: 9 Pages: 126-126
  • DOI: 10.3389/fnmol.2016.00126
  • Peer Reviewed / Open Access
• [Journal Article] PACAP Protects the Adolescent and Adult Mice Brain from Ethanol Toxicity and Modulates Distinct Sets of Genes Regulating Similar Networks (2016)
  • Author(s): Lacaille H, Duterte-Boucher D, Vaudry H, Zerdoumi Y, Flaman JM, Hashimoto H, Vaudry D.
  • Journal Title: Mol. Neurobiol. Volume: 印刷中 Issue: 9 Pages: 7534-7548
  • DOI: 10.1007/s12035-016-0204-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction. (2016)
  • Author(s): Onaka Y, Shintani N, Nakazawa T, Kanoh T, Ago Y, Matsuda T, Hashimoto R, Ohi K, Hirai H, Nagata KY, Nakamura M, Kasai A, Hayata-Takano A, Nagayasu K, Takuma K, Ogawa A, Baba A, Hashimoto H.
  • Journal Title: Behav Brain Res. Volume: 314 Pages: 477-486
  • DOI: 10.1016/j.bbr.2016.07.050
  • Peer Reviewed / Open Access
• [Journal Article] Prenatal Exposure to Histone Deacetylase Inhibitors Affects Gene Expression of Autism-Related Molecules and Delays Neuronal Maturation (2016)
  • Author(s): Kawanai T, Ago Y, Watanabe R, Inoue A, Taruta A, Onaka Y, Hasebe S, Hashimoto H, Matsuda T, Takuma K.
  • Journal Title: Neurochem. Res. Volume: 41(10) Issue: 10 Pages: 2574-2584
  • DOI: 10.1007/s11064-016-1969-y
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism (2016)
  • Author(s): Hara Y, Ago Y, Taruta A, Katashiba K, Hasebe S, Takano E, Onaka Y, Hashimoto H, Matsuda T, Takuma K
  • Journal Title: Autism Research Volume: - Issue: 9 Pages: 926-939
  • DOI: 10.1002/aur.1596
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency (2016)
  • Author(s): Ago Y, Hasebe S, Hiramatsu N, Mori K, Watabe Y, Onaka Y, Hashimoto H, Takuma K, Matsuda T.
  • Journal Title: Psychopharmacology(Berl) Volume: 233(17) Issue: 17 Pages: 3125-3134
  • DOI: 10.1007/s00213-016-4353-3
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers (2016)
  • Author(s): Kormos V, Gaspar L, Kovacs, Farkas J, Gaszner T, Csernus V, Balogh A, Hashimoto H, Reglodi D, Helyes Z, Gaszner B.
  • Journal Title: Neuroscience Volume: 330 Pages: 335-358
  • DOI: 10.1016/j.neuroscience.2016.06.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] PACAP suppresses dry eye signs by stimulating tear secretion (2016)
  • Author(s): Nakamachi T, Ohtaki H, Seki T, Yofu S, Kagami N, Hashimoto H, Shintani N, Baba A, Mark L, Lanekoff I, Kiss P, Farkas J, Reglodi D, Shioda S.
  • Journal Title: Nat. Commun. Volume: 7 Issue: 1 Pages: 12034-12034
  • DOI: 10.1038/ncomms12034
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ (2016)
  • Author(s): Matsumura K, Nakazawa T, Nagayasu K, Gotoda-Nishimura N, Kasai A, Hayata-Takano A, Shintani N, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H.
  • Journal Title: J. Mol. Psychiatry Volume: 4 Issue: 1 Pages: 1-1
  • DOI: 10.1186/s40303-016-0016-x
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) is involved in adult mouse hippocampal neurogenesis after stroke (2016)
  • Author(s): Matsumoto M, Nakamachi T, Watanabe J, Sugiyama K, Ohtaki H, Murai N, Sasaki S, Xu Z, Hashimoto H, Seki T, Miyazaki A, Shioda S.tsumura K, Kawashima H, Yamamori H, Fujimoto M, Ohi K, Umeda-Yano S, Fukunaga M, Fujino H, Kasai A, Hayata-Takano A, Shintani N, Takeda M, Matsumoto N, Hashimoto H.
  • Journal Title: J Mol Neurosci. Volume: 未定
  • Peer Reviewed
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor. (2016)
  • Author(s): Xu Z, Ohtaki H, Watanabe J, Miyamoto K, Murai N, Sasaki S, Matsumoto M, Hashimoto H, Hiraizumi Y, Numazawa S, Shioda S.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 22373-22373
  • DOI: 10.1038/srep22373
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders (2016)
  • Author(s): Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M.
  • Journal Title: Nat Commun. Volume: 7 Issue: 1 Pages: 10594-10594
  • DOI: 10.1038/ncomms11466
  • NAID: 120006535052
  • Peer Reviewed / Open Access
• [Journal Article] Rivastigmine improves isolation rearing-induced prepulse inhibition deficits via muscarinic acetylcholine receptors in mice (2016)
  • Author(s): Higashino K, Ago Y, Umeki T, Hasebe S, Onaka Y, Hashimoto H, Takuma K, Matsuda T.
  • Journal Title: Psychopharmacology (Berl). Volume: 233(3) Issue: 3 Pages: 521-528
  • DOI: 10.1007/s00213-015-4123-7
  • Peer Reviewed
• [Journal Article] Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder. (2015)
  • Author(s): Hashimoto R, Nakazawa T, Tsurusaki Y, Yasuda Y, Nagayasu K, Matsumura K, Kawashima H, Yamamori H, Fujimoto M, Ohi K, Umeda-Yano S, Fukunaga M, Fujino H, Kasai A, Hayata-Takano A, Shintani N, Takeda M, Matsumoto N, Hashimoto H.
  • Journal Title: Journal of Human Genetics Volume: 61 Issue: 3 Pages: 199-206
  • DOI: 10.1038/jhg.2015.141
  • Peer Reviewed / Open Access
• [Journal Article] Structured line illumination Raman microscopy (2015)
  • Author(s): Watanabe K, Palonpon AF, Smith NI, Chiu LD, Kasai A, Hashimoto H, Kawata S, Fujita K.
  • Journal Title: Nat Commun. Volume: 6 Issue: 1 Pages: 10095-10095
  • DOI: 10.1038/ncomms10095
  • Peer Reviewed / Open Access
• [Journal Article] The female encounter test, a novel method for evaluating reward-seeking behavior or motivation in mice (2015)
  • Author(s): Ago Y, Hasebe S, Nishiyama S, Oka S, Onaka Y, Hashimoto H, Takuma K, Matsuda T.
  • Journal Title: Neuropsychopharmacol. Volume: 18(11) Issue: 11 Pages: pyv062-pyv062
  • DOI: 10.1093/ijnp/pyv062
  • Peer Reviewed / Open Access
• [Journal Article] Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice (2015)
  • Author(s): Hasebe S, Ago Y, Nishiyama S, Oka S, Hashimoto H, Takuma K, Matsuda T.
  • Journal Title: Behav Pharmacol. Volume: 26(7) Issue: 7 Pages: 681-690
  • DOI: 10.1097/fbp.0000000000000140
  • Peer Reviewed
• [Journal Article] Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist (2015)
  • Author(s): Ago Y, Condro MC, Tan YV, Ghiani CA, Colwell CS, Cushman JD, Fanselow MS, Hashimoto H, Waschek JA.
  • Journal Title: Psychopharmacology (Berl). Volume: 232(12) Issue: 12 Pages: 2181-2189
  • DOI: 10.1007/s00213-014-3848-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). (2015)
  • Author(s): hibasaki Y, Hayata-Takano A, Hazama K, Nakazawa T, Shintani N, Kasai A, Nagayasu K, Hashimoto R, Tanida M, Katayama T, Matsuzaki S, Yamada K, Taniike M, Onaka Y, Ago Y, Waschek JA, Köves K, Reglődi D, Tamas A, Matsuda T, Baba A, Hashimoto H.
  • Journal Title: Neuroscience Volume: 297 Pages: 95-104
  • DOI: 10.1016/j.neuroscience.2015.03.062
  • Peer Reviewed
• [Journal Article] Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model (2015)
  • Author(s): Hara Y, Takuma K, Takano E, Katashiba K, Taruta A, Higashino K, Hashimoto H, Ago Y, Matsuda T.
  • Journal Title: Behav Brain Res. Volume: 289 Pages: 39-47
  • DOI: 10.1016/j.bbr.2015.04.022
  • Peer Reviewed
• [Journal Article] CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice (2015)
  • Author(s): Yusuke Onaka, Norihito Shintani, Takanobu Nakazawa, Ryota Haba, Yukio Ago, Hyper Wang, Takuya Kanoh, Atsuko Hayata-Takano, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Ryota Hashimoto, Toshio Matsuda, James A. Waschek, Atsushi Kasai, Kazuki Nagayasu, Akemichi Baba, Hitoshi Hashimoto
  • Journal Title: Behavioural Brain Research Volume: 284 Pages: 131-137
  • DOI: 10.1016/j.bbr.2015.02.013
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Anxiolytic-like effects of restraint during the dark cycle in adolescent mice (2015)
  • Author(s): Ota Y, Ago Y, Tanaka T, Hasebe S, Toratani Y, Onaka Y, Hashimoto H, Takuma K, Matsuda T
  • Journal Title: Behavioural Brain Research Volume: 284 Pages: 103-111
  • DOI: 10.1016/j.bbr.2015.02.010
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Identification of the role of BMP and TGF-β signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro. (2015)
  • Author(s): Yamasaki A, Kasai A, Toi A, Kurita M, Kimoto S, Hayata-Takano A, Nakazawa T, Nagayasu K, Shintani N, Hashimoto R, Ito A, Meltzer HY, Ago Y, Waschek JA, Onaka Y, matsuda T, Baba A, Hashimoto H.
  • Journal Title: Journal of Neurochemistry, Volume: 132(4) Issue: 4 Pages: 418-428
  • DOI: 10.1111/jnc.12999
  • Peer Reviewed / Open Access
• [Journal Article] Simultaneous neuron- and astrocyte-specific fluorescent marking. (2015)
  • Author(s): Schulze W, Hayata-Takano A, Kamo T, Nakazawa T, Nagayasu K, Kasai A, Seiriki K, Shintani N, Ago Y, Farfan C, Hashimoto R, Baba A, Hashimoto H.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 459 Issue: 1 Pages: 81-86
  • DOI: 10.1016/j.bbrc.2015.02.073
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] PACAP Enhances Axon Outgrowth in Cultured Hippocampal Neurons to a Comparable Extent as BDNF. (2015)
  • Author(s): Ogata K, Shintani N, Hayata-takano A, Kamo T, Higashi S, Seiriki K, Momosaki H, Vaudy D, Vaudy H, Galas L, Kasai A, Nagayasu K, Nakazawa T, Hashimoto R, Ago Y, Matsuda T, Baba A, Hashimoto H.
  • Journal Title: PLoS One Volume: 10 Issue: 3 Pages: e0120526-e0120526
  • DOI: 10.1371/journal.pone.0120526
  • Peer Reviewed / Open Access
• [Journal Article] A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells. (2015)
  • Author(s): Malchenko S, Sredni ST, Hashimoto H, Kasai A, Nagayasu K, Xie J, Margaryan NV, Seiriki K, Lulla RR, Seftor RE, Pachman LM, Meltzer HY, Hendrix MJ, Soares MB
  • Journal Title: PLoS One Volume: 10 Issue: 3 Pages: e0121707-e0121707
  • DOI: 10.1371/journal.pone.0121707
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Characterization of the thermoregulatory response to pituitary adenylate cyclase-activating polypeptide in rodents. (2014)
  • Author(s): Banki E, Pakai E, Gaszner B, Zsiboras C, Czett A, Bhuddi PR, Hashimoto H, Toth G, Tamas A, Reglodi D, Garami A
  • Journal Title: J Mol Neurosci Volume: 54 Issue: 3 Pages: 543-554
  • DOI: 10.1007/s12031-014-0361-0
  • Peer Reviewed
• [Journal Article] Differential regulatory role of pituitary adenylate cyclase-activating polypeptide in the serum-transfer arthritis model. (2014)
  • Author(s): Botz B, Bolcskei K, Kereskai L, Kovacs M, Nemeth T, Szigeti K, Horvath I, Mathe D, Kovacs N, Hashimoto H, Reglodi D, Szolcsanyi J, Pinter E, Mocsai A, Helyes Z
  • Journal Title: Arthritis Rheumatol Volume: 66 Issue: 10 Pages: 2739-2750
  • DOI: 10.1002/art.38772
  • Peer Reviewed / Open Access
• [Journal Article] Comparative protein composition of the brains of PACAP-deficient mice using mass spectrometry-based proteomic analysis. (2014)
  • Author(s): Maasz G, Pirger Z, Reglodi D, Petrovics D, Schmidt J, Kiss P, Rivnyak A, Hashimoto H, Avar P, Jambor E, Tamas A, Gaszner B, Mark L
  • Journal Title: J Mol Neurosci Volume: 54 Issue: 3 Pages: 310-319
  • DOI: 10.1007/s12031-014-0264-0
  • Peer Reviewed
• [Journal Article] Structural and morphometric comparison of the molar teeth in pre-eruptive developmental stage of PACAP-deficient and wild-type mice. (2014)
  • Author(s): Sandor B, Fintor K, Felszeghy S, Juhasz T, Reglodi D, Mark L, Kiss P, Jungling A, Fulop BD, Nagy AD, Hashimoto H, Zakany R, Nagy A, Tamas A.
  • Journal Title: J Mol Neurosci. Volume: 54(3) Issue: 3 Pages: 331-341
  • DOI: 10.1007/s12031-014-0392-6
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Behavioral characterization of mice overexpressing human dysbindin-1 (2014)
  • Author(s): Shintani N, Onaka Y, Hashimoto R, Takamura H, Nagata T, Umeda-Yano S, Mouri A, Mamiya T, Haba R, Matsuzaki S, Katayama T, Yamamori H, Nakazawa T, Nagayasu K, Ago Y, Yagasaki Y, Nabeshima T, Takeda M, Hashimoto H
  • Journal Title: Molecular Brain Volume: 7(1) Issue: 1 Pages: 74-74
  • DOI: 10.1186/s13041-014-0074-x
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism. (2014)
  • Author(s): Takuma K, Hara Y, Kataoka S, Kawanai T, Maeda Y, Watanabe R, Takano E, Hayata-Takano A, Hashimoto H, Ago Y, Matsuda T.
  • Journal Title: Pharmacol Biochem Behav. Volume: 126 Pages: 43-49
  • DOI: 10.1016/j.pbb.2014.08.013
  • Peer Reviewed
• [Journal Article] An enriched environment ameliorates memory impairments in PACAP-deficient mice. (2014)
  • Author(s): Takuma K, Maeda Y, Ago Y, Ishihama T, Takemoto K, Nakagawa A, Shintani N, Hashimoto H, Baba A, Matsuda T
  • Journal Title: Behav Brain Res Volume: 272 Pages: 269-278
  • DOI: 10.1016/j.bbr.2014.07.005
  • Peer Reviewed
• [Journal Article] Role of the 5-HT1A Autoreceptor in the Enhancement of Fluvoxamine-Induced Increases in Prefrontal Dopamine Release by Adrenalectomy/Castration in Mice. (2014)
  • Author(s): Hasebe S, Hiramatsu N, Ago Y, Mori K, Watabe Y, Hashimoto H, Takuma K, Matsuda T
  • Journal Title: Journal of Pharmacological Sciences Volume: 127 Issue: 2 Pages: 232-235
  • DOI: 10.1016/j.jphs.2015.01.001
  • Peer Reviewed
• [Presentation] High-speed whole brain imaging with subcellular resolution and comparison analysis (2017)
  • Author(s): 笠井淳司、橋本均
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-24
• [Presentation] 精神的ストレスにより活性化する神経核の情動行動における役割 (2017)
  • Author(s): 丹生光咲、笠井淳司、勢力薫、五十嵐久人、山口瞬、山中章弘、中澤敬信、橋本均
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-24
• [Presentation] 全脳活動マッピングを用いたNMDA受容体拮抗薬誘発行動異常にかかわる脳部位の解析 (2017)
  • Author(s): 勢力薫、笠井淳司、桑木崇宏、丹生光咲、中雄一郎、五十嵐久人、中澤敬信、山口瞬、吾郷由希夫、橋本均
  • Organizer: 第90回薬理学会年会
  • Place of Presentation: 長崎
  • Year and Date: 2017-03-15
• [Presentation] CNS創薬を支援する疾患モデルの開発 (2017)
  • Author(s): 橋本均、笠井淳司、中澤敬信
  • Organizer: 日本安全性薬理研究会第8回学術年会
  • Place of Presentation: 東京
  • Year and Date: 2017-02-10
• [Presentation] Activation of the VPAC2 receptor inhibits neurite outgrowth and branching of cortical neurons by a PKA-dependent mechanism (2016)
  • Author(s): Hashimoto H, Ago Y, Hayata-Takano A, Kawanai T, Yamauchi R, Waschek JA.
  • Organizer: Neuroscience 2016
  • Place of Presentation: アメリカ
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] 全脳イメージングによる脳機能・疾患機序の解析 (2016)
  • Author(s): 橋本均、勢力薫、丹生光咲、中雄一郎、笠井淳司
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会
  • Place of Presentation: 福岡
  • Year and Date: 2016-09-08
• [Presentation] 神経細胞の成熟におけるPACAPとBDNFの役割 (2016)
  • Author(s): 早田 敦子、加茂 俊彦、勢力 薫、尾形 勝弥、中澤 敬信、吾郷 由希夫、永安 一樹、笠井 淳司、新谷 紀人、橋本 均
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会
  • Place of Presentation: 福岡
  • Year and Date: 2016-09-08
• [Presentation] Overactivation of the VPAC2 receptor during the early postnatal period causes prefrontal synaptic abnormalities and cognitive dysfundtion in mice (2016)
  • Author(s): Ago Y, Hayata A, Kawanai T, Yamauchi R, Waschek JA, Hashimoto H.
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: 韓国
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] iPS細胞技術を用いた統合失調症患者のクロザピン応答性の個人間の相違の分子機構解析 (2016)
  • Author(s): 中澤敬信、橋本亮太、橋本均
  • Organizer: 第46回日本神経精神薬理学会年会
  • Place of Presentation: 韓国
  • Year and Date: 2016-07-02
• [Presentation] 精神的ストレスによる覚せい剤精神病の再燃現象におけるセロトニン受容体の関与 (2016)
  • Author(s): 田中辰典、吾郷由希夫、梅原千晶、長谷部茂、橋本均、田熊一敞、松田敏夫
  • Organizer: 第13回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-05-13
• [Presentation] 統合失調症におけるVIP/PACAP受容体VPAC2活性化の病態的意義 (2016)
  • Author(s): 吾郷由希夫、河内琢也、山内良介、早田敦子、James Waschek、橋本均
  • Organizer: 第13回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-05-13
• [Presentation] 発育期の環境要因が精神・神経機能に及ぼす影響 (2016)
  • Author(s): 田熊一敞, 吾郷由希夫, 長谷部茂, 橋本均, 松田敏夫
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜（神奈川・横浜市）
  • Year and Date: 2016-03-09
  • Int'l Joint Research
• [Presentation] 精神疾患の分子機構の解析と創薬に向けた疾患モデル研究 (2016)
  • Author(s): 橋本均
  • Organizer: 第61回脳の医学・生物学研究会
  • Place of Presentation: 韓国
  • Invited
• [Presentation] Whole Brain Imaging to Investigate Physiology and Pathophysiology of Brain Disorders (2016)
  • Author(s): Hashimoto H.
  • Organizer: VIMM Seminar (日伊国交150周年事業)
  • Place of Presentation: イタリア
  • Int'l Joint Research / Invited
• [Presentation] がん治療後に認められる高次脳機能障害におけるシクロオキシゲナーゼの関与 (2016)
  • Author(s): 尾中勇祐、新谷紀人、中澤敬信、吾郷由希夫、木野村 元彦、田邊 航、荻田 喜代一、橋本 均
  • Organizer: 第130回日本薬理学会近畿部会
  • Place of Presentation: 京都
• [Presentation] 脳病態を解明するモデル動物の全脳イメージング (2015)
  • Author(s): 橋本均, 笠井淳司, 勢力薫, 丹生光咲, 中澤敬信
  • Organizer: 第6回脳表現型の分子メカニズム研究会
  • Place of Presentation: コンベンションルームAP品川アネックスIルーム（東京・品川区）
  • Year and Date: 2015-11-14
  • Int'l Joint Research
• [Presentation] A new block-face serial microscopy tomography for computational mapping of brain cells, and unbiased comparative analysis (2015)
  • Author(s): Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Nakazawa T, Hashimoto H.
  • Organizer: 45th Society for Neuroscience Annual meeting (Neuroscience2015)
  • Place of Presentation: シカゴ（アメリカ）
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Practical optimization of in situ hybridization procedure for the detection of microRNAs and mRNA expression in brain tissues (2015)
  • Author(s): Kasai A, Kakihara S, Okada R, Hazama K, Nakazawa T, Nagayasu K, Hayata-Takano A, Shintani N, Hashimoto H.
  • Organizer: 45th Society for Neuroscience Annual meeting (Neuroscience2015)
  • Place of Presentation: シカゴ（アメリカ）
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Overactivation of the VPAC2 receptor during postnatal brain development causes prefrontal synaptic abnormalities and cognitive dysfunction in mice (2015)
  • Author(s): Ago Y, Condro MC, Tan YV, Hayata A, Kawanai T, Cushman JD, Fanselow MS, Hashimoto H, Waschek JA.
  • Organizer: 12th International Symposium on VIP/PACAP and Related Peptides
  • Place of Presentation: カッパドキア（トルコ）
  • Year and Date: 2015-09-21
  • Int'l Joint Research
• [Presentation] Roles of PACAP in Depressopm-Like Behavior (2015)
  • Author(s): Hashimoto H, Shintani N, Ago Y, Hayata-Takano A, Waschek JA, Baba A.
  • Organizer: 12th International Symposium on VIP/PACAP and Related Peptides
  • Place of Presentation: カッパドキア（トルコ）
  • Year and Date: 2015-09-21
  • Int'l Joint Research
• [Presentation] ストレスにより活性化する神経細胞の全脳マッピングと定量的解析 (2015)
  • Author(s): 丹生光咲, 笠井淳司, 勢力薫, 山口瞬, 橋本岳, 中澤敬信, 橋本均
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム2015
  • Place of Presentation: 東京大学薬学部（東京・文京区）
  • Year and Date: 2015-08-29
• [Presentation] 構造および神経活動の変化を定量的に検出する高精細三次元全脳形態計測システム (2015)
  • Author(s): 勢力薫, 笠井淳司, 丹生光咲, 山口瞬, 橋本岳, 中澤敬信, 橋本均
  • Organizer: 第38回日本神経科学会大会
  • Place of Presentation: 神戸国際会議場（兵庫・神戸市）
  • Year and Date: 2015-07-28
• [Presentation] 自閉症の疾患特異的候補遺伝子の機能的スクリーニング (2015)
  • Author(s): 松村憲佑, 橋本亮太, 中澤敬信, 鶴崎美徳, 安田由華, 永安一樹, 川島和, 山森英長, 藤本美智子, 大井一高, 梅田知美, 福永雅喜, 藤野陽生, 笠井淳司, 早田敦子, 新谷紀人, 武田雅俊, 松本直通, 橋本均
  • Organizer: 第38回日本神経科学会大会
  • Place of Presentation: 神戸国際会議場（兵庫・神戸市）
  • Year and Date: 2015-07-28
• [Presentation] 雌選択性試験：マウス間相互作用を基盤とした新規うつ様行動評価系 (2015)
  • Author(s): 長谷部茂, 岡智史, 尾中勇祐, 橋本均, 松田敏夫, 吾郷由希夫, 田熊一敞
  • Organizer: 第38回日本神経科学会大会
  • Place of Presentation: 神戸国際会議場（兵庫・神戸市）
  • Year and Date: 2015-07-28
• [Presentation] マウス活動期における拘束ストレスは抗不安様作用を示す (2015)
  • Author(s): 田中辰典, 太田友樹, 大住康晃, 長谷部茂, 尾中勇祐, 橋本均, 松田敏夫, 田熊一敞, 吾郷由希夫
  • Organizer: 第38回日本神経科学会大会
  • Place of Presentation: 神戸国際会議場（兵庫・神戸市）
  • Year and Date: 2015-07-28
• [Presentation] リバスチグミンのムスカリン受容体を介したプレパルスインヒビション障害改善作用 (2015)
  • Author(s): 東野功典, 梅木孝弘, 尾中勇祐, 橋本均, 松田敏夫, 田熊一敞, 吾郷由希夫
  • Organizer: 第38回日本神経科学会大会
  • Place of Presentation: 神戸国際会議場（兵庫・神戸市）
  • Year and Date: 2015-07-28
• [Presentation] がん治療後の脳機能障害の解明に有用な動物モデルの作製 (2015)
  • Author(s): 尾中勇祐, 木野村元彦, 新谷紀人, 平井博之, 永田欽也, 中村正孝, 長谷部茂, 永安一樹, 吾郷由希夫, 笠井淳司, 早田敦子, 中澤敬信, 田熊一敞, 松田敏夫, 馬場明道, 橋本均
  • Organizer: 第127回日本薬理学会近畿部会
  • Place of Presentation: 長良川国際会議場（岐阜・岐阜市）
  • Year and Date: 2015-06-26
• [Presentation] 高精細三次元定量的全脳解析システムの構築と脳内変化の検出 (2015)
  • Author(s): 笠井 淳司、勢力 薫、丹生 光咲、橋本 岳、橋本 均
  • Organizer: 日本薬学会 第135年会（神戸）
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] 慢性的な社会的敗北ストレスによる内側前頭前皮質におけるPACAP発現低下とエピジェネティクス関連因子の発現変化 (2015)
  • Author(s): 川瀬 啓生、笠井 淳司、小川 純明、狭間 啓佑、早田 敦子、新谷 紀人、馬場 明道、橋本 均
  • Organizer: 日本薬学会 第135年会（神戸）
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] 高精細全脳形態計測システムの構築 (2015)
  • Author(s): 勢力 薫、笠井 淳司、丹生 光咲、山口 瞬、橋本 岳、橋本 均
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] International collaborative research focusing on the oxidative stress hypothesis for novel drug development in psychiatric diseases. (2015)
  • Author(s): Hashimoto H
  • Organizer: 医学研セミナー
  • Place of Presentation: 東京
  • Year and Date: 2015-01-23
  • Invited
• [Presentation] 高精細三次元定量的全脳解析法の構築：マイクロエンドフェのタイプの探索へ (2014)
  • Author(s): 笠井 淳司、勢力 薫、丹生 光咲、橋本 岳、橋本 均
  • Organizer: 2014年度包括脳ネットワーク冬のシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2014-12-12 – 2014-12-13
• [Presentation] 自閉スペクトラム症関連候補遺伝子のハイスループット機能評価系による解析 (2014)
  • Author(s): 永安 一樹、松村 憲佑、中澤 敬信、安田 由華、山森 英長、梅田 知美、大井 一高、橋本 亮太、武田 雅俊、橋本 均
  • Organizer: 2014年度包括脳ネットワーク冬のシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2014-12-12 – 2014-12-13
• [Presentation] Brain-enriched Sorting Nexin Family Proteins Regulate Spine Morphogenesisand Are Associated with Risk for Schizophrenia (2014)
  • Author(s): Nakazawa T, Hashimoto R, Tanimura A, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M
  • Organizer: ACNP 53rd Annual Meeting
  • Place of Presentation: Phoenix, AZ , USA
  • Year and Date: 2014-12-07 – 2014-12-11
• [Presentation] アメリカにおける神経精神薬理学会の動向 (2014)
  • Author(s): 橋本 均
  • Organizer: 第24回 日本臨床精神神経薬理学会 第44回日本神経精神薬理学会 合同年会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-11-20 – 2014-11-22
  • Invited
• [Presentation] iPS細胞関連技術を用いた統合失調症研究 (2014)
  • Author(s): 中澤 敬信、橋本 亮太、永安 一樹、安田 由華、山森 英長、梅田 知美、藤本 美智子、大井 一高、石川 充、赤松 和土、岡野 栄之、武田 雅俊、橋本 均
  • Organizer: 第24回 日本臨床精神神経薬理学会 第44回日本神経精神薬理学会 合同年会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-11-20 – 2014-11-22
  • Invited
• [Presentation] 自閉症の疾患特異的候補遺伝子の機能的スクリーニング系の確立 (2014)
  • Author(s): 松村 憲佑、永安 一樹、中澤 敬信、安田 由華、山森 英長、梅田 知美、大井 一高、橋本 亮太、武田 雅俊、橋本 均
  • Organizer: 第24回 日本臨床精神神経薬理学会 第44回日本神経精神薬理学会 合同年会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-11-20 – 2014-11-22
• [Presentation] LPS誘発炎症モデルにおいて発現変化する脳内miRNAの同定 (2014)
  • Author(s): 柿原 素楽、笠井 淳司、岡田 遼、尾中 勇祐、中澤 敬信、永安 一樹、早田 敦子、新谷 紀人、橋本 均
  • Organizer: 第126回 日本薬理学会 近畿部会
  • Place of Presentation: 和歌山
  • Year and Date: 2014-10-24
• [Presentation] PRABβ（σ）遺伝子欠損マウスの行動表現型に関する検討 (2014)
  • Author(s): 本郷 翔子、中田 理恵子、尾中 勇祐、新谷 紀人、橋本 均、井上 裕康
  • Organizer: 第87回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 神経ペプチドPACAPによる精神機能調節：創薬への展望 (2014)
  • Author(s): 橋本 均、新谷 紀人、早田 敦子、笠井 淳司、永安 一樹、中澤 敬信
  • Organizer: 第36回日本生物学的精神医学会 第57回日本神経化学会大会 合同年会
  • Place of Presentation: 奈良
  • Year and Date: 2014-09-29 – 2014-10-01
• [Presentation] 精神・神経疾患モデル動物の病態解析のための三次元全脳形態計測法の構築 (2014)
  • Author(s): 勢力 薫、笠井 淳司、丹生 光咲、早田 敦子、永安 一樹、中澤 敬信、新谷 紀人、橋本 岳、橋本 均
  • Organizer: 第36回日本生物学的精神医学会 第57回日本神経化学会大会 合同年会
  • Place of Presentation: 奈良
  • Year and Date: 2014-09-29 – 2014-10-01
• [Presentation] A crosstalk between PACAP and serotonin 2A signaling (2014)
  • Author(s): 森口 啓太、早田 敦子、道添 瞳、円丁 直樹、新谷 紀人、馬場 明道、橋本 均
  • Organizer: 20th International Symposium on Regulatory Peptides (REGPEG2014)
  • Place of Presentation: 京都
  • Year and Date: 2014-09-07 – 2014-09-10
• [Presentation] ミトコンドリア融合抑制因子MIFIの転写を調節する化合物の探索. (2014)
  • Author(s): 廣内 大成、井上 直紀、新谷 紀人、田中 翔大、笠井 淳司、馬場 明道、橋本 均
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム2014
  • Place of Presentation: 大阪
  • Year and Date: 2014-08-30
• [Presentation] 細胞内タンパク質輸送と統合失調症 (2014)
  • Author(s): 中澤 敬信、橋本 亮太、橋本 均
  • Organizer: 生体機能と創薬シンポジウム2014
  • Place of Presentation: 大阪
  • Year and Date: 2014-08-28 – 2014-08-29
• [Presentation] コルチコステロン誘発性うつ病モデルを用いたプロスタノイド受容体DP2を介する情動制御機構の解析 (2014)
  • Author(s): 尾中 勇祐、新谷 紀人、木野村 元彦、平井 博之、長田 欽也、中村 正孝、早田 敦子、笠井 淳司、永安 一樹、中澤 敬信、馬場 明道、橋本 均
  • Organizer: 生体機能と創薬シンポジウム2014
  • Place of Presentation: 大阪
  • Year and Date: 2014-08-28 – 2014-08-29
• [Presentation] 脳内miRNA発現の高感度検出に向けたin situ hybridization法の最適化：炎症により発現変化する脳内miRNAの同定 (2014)
  • Author(s): 柿原 素楽、笠井 淳司、岡田 遼、狭間 啓佑、中澤 敬信、永安 一樹、早田 敦子、新谷 紀人、橋本 均
  • Organizer: 生体機能と創薬シンポジウム2014
  • Place of Presentation: 大阪
  • Year and Date: 2014-08-28 – 2014-08-29
• [Presentation] PACAP-PAC1 signaling pathway regulates internalization of serotonin 2A receptor in a PKC and.b-arrestin2 dependent manner (2014)
  • Author(s): 早田 敦子、森口 啓太、円丁 直樹、新谷 紀人、馬場 明道、橋本 均
  • Organizer: 29th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-06-22 – 2014-06-26
• [Presentation] ミトコンドリア融合阻害因子MIFIによる心病態の増悪機序に関する解析:遺伝子発現プロフィール解析. (2014)
  • Author(s): 田中 翔大、新谷 紀人、中山 博之、東 信太朗、開 菜摘、舎川 洸太、藤尾 慈、井上 直紀、笠井 淳司、早田 敦子、橋本 均、馬場 明道
  • Organizer: 第125回 日本薬理学会 近畿部会
  • Place of Presentation: 岡山
  • Year and Date: 2014-06-20
• [Remarks] 大阪大学大学院 薬学研究科 神経薬理学分野
  • URL: http://molpharm.umin.jp/index.html