Identification of a Vesicle specific D-serine transporter in the brain.
| Project/Area Number |
26670123
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
YOSHIKATSU Kanai 大阪大学, 医学(系)研究科(研究院), 教授 (60204533)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHGAKI Ryuichi 大阪大学, 大学院医学系研究科, 助教 (20467525)
OKUDA Suguru 大阪大学, 医学系研究科, 助教 (50511846)
NAGAMORI Shushi 大阪大学, 大学院医学系研究科, 准教授 (90467572)
|
|---|
| Project Period (FY) |
2014-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
|---|
| Keywords | 受容体 / チャネル / 輸送系 / シグナル情報伝達系 |
|---|
| Outline of Final Research Achievements |
D-serine is an endogenous D-amino acid abundant in the mammalian brain. The main target of D-serine is the NMDA receptor, which has important roles in learning, memory and neurodegenerative diseases. However, how D-serine is regulated in the brain still remains to be clarified. Here we have revealed that y+Asc-1 is a neuron specific D-serine transporter and involved in the neuron-derived D-serine release in the brain. Our findings would provide a new insight into the neural D-serine study and contribute to the understanding of D-serine function in the brain.
|
Report
(2 results)
Research Products
(19 results)
-
[Journal Article] Development of a Widely Usable Amino Acid Tracer: 76Br-α-Methyl-Phenylalanine for Tumor PET Imaging.2015
Author(s)
Hanaoka H, Ohshima Y, Suzuki Y, Yamaguchi A, Watanabe S, Uehara T, Nagamori S, Kanai Y, Ishioka NS, Tsushima Y, Endo K, Arano Y.
-
Journal Title
Related Report
Peer Reviewed
-
[Journal Article] Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB(0,+) , LAT1 and LAT2.2015
Author(s)
Wongthai P, Hagiwara K, Miyoshi Y, Wiriyasermkul P, Wei L, Ohgaki R, Kato I, Hamase K, Nagamori S, Kanai Y.
-
Journal Title
Cancer Sci.
Volume: 106
Issue: 3
Pages: 279-86
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
[Journal Article] Expression of L-type amino acid transporter 1 (LAT1) as a prognostic and therapeutic indicator in multiple myeloma.2014
Author(s)
Isoda A, Kaira K, Iwashina M, Oriuchi N, Tominaga H, Nagamori S, Kanai Y, Oyama T, Asao T, Matsumoto M, Sawamura M.
-
Journal Title
Cancer Sci.
Volume: 105
Issue: 11
Pages: 1496-502
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
