| Project/Area Number |
26670123
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
YOSHIKATSU Kanai 大阪大学, 医学(系)研究科(研究院), 教授 (60204533)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHGAKI Ryuichi 大阪大学, 大学院医学系研究科, 助教 (20467525)
OKUDA Suguru 大阪大学, 医学系研究科, 助教 (50511846)
NAGAMORI Shushi 大阪大学, 大学院医学系研究科, 准教授 (90467572)
|
|---|
| Project Period (FY) |
2014-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
|---|
| Keywords | 受容体 / チャネル / 輸送系 / シグナル情報伝達系 |
|---|
| Outline of Final Research Achievements |
D-serine is an endogenous D-amino acid abundant in the mammalian brain. The main target of D-serine is the NMDA receptor, which has important roles in learning, memory and neurodegenerative diseases. However, how D-serine is regulated in the brain still remains to be clarified. Here we have revealed that y+Asc-1 is a neuron specific D-serine transporter and involved in the neuron-derived D-serine release in the brain. Our findings would provide a new insight into the neural D-serine study and contribute to the understanding of D-serine function in the brain.
|
