Elucidation of a new differentiation mechanism of beige adipocytes and its application for drug design
Project/Area Number |
26670124
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
General pharmacology
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Research Institution | Kobe University |
Principal Investigator |
SAITO NAOAKI 神戸大学, バイオシグナル研究センター, 教授 (60178499)
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Co-Investigator(Kenkyū-buntansha) |
UEYAMA Takehiko 神戸大学, バイオシグナル研究センター, 准教授 (80346254)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 脂肪細胞 / 分化誘導因子 / ケラチノサイト / Rac |
Outline of Final Research Achievements |
We studied a new Rac-medicated pathway which can induce the differentiation of adipocytes. Using DNA microarray and RT-PCR, we found 5 factors (a,b,c,d,e) secreted from keraninocytes when Rac-mediated pathway is activated. Differentiation of adipocyte (3T3-L1 cells) was significantly enhanced when the cells were treated with the combination of a+b or a+c, much more than treated with a, b or c alone. We further elucidate whether the signal induces the diffentiation to white or beige adipocyte and we study the new drug target for the disorder of lipid/glucose metabolim.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.2015
Author(s)
Takahashi H, Adachi N, Shirafuji T, Danno S, Ueyama T, Vendruscolo M, Shuvaev AN, Sugimoto T, Seki T, Hamada D, Irie K, Hirai H, Sakai N, *Saito N.
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Journal Title
Hum Mol Genet.
Volume: 24
Issue: 2
Pages: 525-539
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The role of Pak-interacting exchange factor-β phosphorylation at serines 340 and 583 by PKCγ in dopamine release.2014
Author(s)
Shirafuji T, Ueyama T, Yoshino K, Takahashi H, Adachi N, Ago Y, Koda K, Nashida T, Hiramatsu N, Matsuda T, Toda T, Sakai N, Saito N.
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Journal Title
J Neurosci
Volume: 34
Issue: 28
Pages: 9268-9280
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells2014
Author(s)
Ueyama T, Sakaguchi H, Nakamura T, Goto A, Morioka S, Shimizu A, Nakao K, Hishikawa Y, Ninoyu Y, Kassai H, Suetsugu S, Koji T, Fritzsch B, Yonemura S, Hisa Y, Matsuda M, Aiba A, Saito N.
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Journal Title
J Cell Sci.
Volume: 127
Pages: 2040-2052
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] RANTES/CCL5 mediated-biological effects depend on the syndecan-4/PKCa signaling pathway2014
Author(s)
Maillard, L., Saito, N., Hlawaty, H., Friand, V., Suffee, N., Chmilewsky, F., Haddad, O., Laguillier, C., Guyot, E., Ueyama, T., Oudar, O., Sutton, A., Charnaux, N.
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Journal Title
Biology Open
Volume: 3
Issue: 10
Pages: 995-1004
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] ・Maintenance of stereocillia and apical junctional complexes by Cdc42 in cochlear hair cells.2014
Author(s)
Ueyama, T., Sakaguchi,H., Nakamura, T., Goto, A., Morioka, S., Fritzsch, B., Hisa, Y., Matsuda, M., Aiba, A. and Saito, N.
Organizer
Society for Neuroscience
Place of Presentation
Washington DC, USA
Year and Date
2014-11-15 – 2014-11-19
Related Report
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[Presentation] Cdc42 is required for maintenance of stereocilia and apical junctional complexes in cochlear hair cells.2014
Author(s)
Ueyama, T., Sakaguchi, H., Goto, A., Hisa, Y., Matsuda, M., Aiba, A. and Saito, N.
Organizer
The 37th Naito Conference,
Place of Presentation
北海道ニセコ
Year and Date
2014-07-15 – 2014-07-18
Related Report