A novel therapeutic strategy for Alzheimer's disease based on the promotion of clearance mechanism of amyloid beta protein
| Project/Area Number |
26670126
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
Iwasa Kensuke 埼玉医科大学, 医学部, 助手 (00623703)
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| Co-Investigator(Kenkyū-buntansha) |
吉川 圭介 埼玉医科大学, 医学部, 講師 (10435860)
柳下 聡介 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第五部, 室長 (30585592)
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| Co-Investigator(Renkei-kenkyūsha) |
Kondo Ryuitiro 九州大学, 農学研究科, 教授 (80091370)
Shimizu Kuniyoshi 九州大学, 農学研究科, 准教授 (20346836)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | アルツハイマー病 / アミロイドβタンパク / Aβ42 / クリアランス / Aβタンパク質 / 天然資源由来抽出物 / アルツハイマー |
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| Outline of Final Research Achievements |
We found a natural resource derived component X, which increased Alzheimer Aβ42 protein in cellular level study. However, mice administrated X for long term were decreased Aβ42 in the brain and showed high level of learning and memory, compared to the control mice. Therefore, it was considered that X may promote the clearance mechanism of Aβ42 in the brain. In this study, we isolated and identified candidate compound Y from the component X with the cellular level study. We are preparing the mice administrated Y for long term. We are planning to Aβ42 production and ability of learning and memory in the Y administrated mice, to reveal the Aβ42 clearance mechanism of candidate compound Y.
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Report
(5 results)
Research Products
(6 results)
