| Project/Area Number |
26670129
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
KUDO Makiko 金沢医科大学, 医学部, 研究員 (50722253)
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| Co-Investigator(Kenkyū-buntansha) |
MASUOKA Takayoshi 金沢医科大学, 医学部, 講師 (80509307)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 海馬 / アセチルコリン / 細胞内受容体 / シナプス伝達長期増強 / ムスカリン受容体 |
|---|
| Outline of Final Research Achievements |
We have reported that muscarinic acetylcholine receptors M1 (M1-mAChRs) are functionally expressed in the intracellular membranes of cortical and hippocampal neurons, and facilitate long-term potentiation (LTP) in hippocampal CA1 synapses. In this study, we clarified whether endogenous agonist acetylcholine activates the intracellular M1-mAChRs and regulates hippocampal synaptic plasticity.
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