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Novel regulation of synaptic plasticity by intracellular acetylcholine receptors

Research Project

Project/Area Number 26670129
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General pharmacology
Research InstitutionKanazawa Medical University

Principal Investigator

KUDO Makiko  金沢医科大学, 医学部, 研究員 (50722253)

Co-Investigator(Kenkyū-buntansha) MASUOKA Takayoshi  金沢医科大学, 医学部, 講師 (80509307)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords海馬 / アセチルコリン / 細胞内受容体 / シナプス伝達長期増強 / ムスカリン受容体
Outline of Final Research Achievements

We have reported that muscarinic acetylcholine receptors M1 (M1-mAChRs) are functionally expressed in the intracellular membranes of cortical and hippocampal neurons, and facilitate long-term potentiation (LTP) in hippocampal CA1 synapses. In this study, we clarified whether endogenous agonist acetylcholine activates the intracellular M1-mAChRs and regulates hippocampal synaptic plasticity.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Long-term activation of group I metabotropic glutamate receptors increases functional TRPV1-expressing neurons in mouse dorsal root ganglia2016

    • Author(s)
      Takayoshi Masuoka* , Makiko Kudo, Junko Yoshida, Takaharu Ishibashi, Ikunobu Muramatsu, Nobuo Kato, Noriko Imaizumi and Matomo Nishio
    • Journal Title

      Front. Cell. Neurosci.

      Volume: 10 Pages: 79-79

    • DOI

      10.3389/fncel.2016.00079

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Biphasic modulation by mGlu5 receptors of TRPV1-mediatedintracellular calcium elevation in sensory neurons contributes to heat sensitivity.2015

    • Author(s)
      Masuoka T, Nakamura T, Kudo M, Yoshida J, Takaoka Y, Kato N, Ishibashi T,
    • Journal Title

      Br J Pharmacol

      Volume: 172 Issue: 4 Pages: 1020-1033

    • DOI

      10.1111/bph.12962

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Biphasic modulation of noxious heat sensitivity in sensory neurons by peripheral metabotropic glutamate receptors2015

    • Author(s)
      Masuoka T, Ishibashi T. and Nishio M.
    • Journal Title

      Inflamm Cell Signal

      Volume: 2

    • DOI

      10.14800/ics.602

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Intracellular localization of the M1 muscarinic acetylcholine receptor through clathrin-dependent constitutive internalization is mediated by a C-terminal tryptophan-based motif.2014

    • Author(s)
      Uwada J, Yoshiki H, Masuoka T, Nishio M, Muramatsu I.
    • Journal Title

      J Cell Sci

      Volume: 127 Pages: 3131-3140

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Contribution of intracellular acetylcholine receptor to hippocampal long-term potentiation reinforced by an irreversible cholinesterase inhibitor2016

    • Author(s)
      Makiko Kudo, Takayoshi Masuoka, Ikunobu Muramatsu, Matomo Nishio
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Electrophysiological characteristics of TRPV1-mediated responses in TRPA1-positive neurons in dorsal root ganglion2016

    • Author(s)
      Takayoshi Masuoka, Makiko Kudo, Takaharu Ishibashi, Matomo Nishio
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 短時間および長時間のグルタミン酸受容体活性化による後根神経節細胞のcapsaicinに対する応答性の変化2015

    • Author(s)
      益岡尚由、工藤麻希子、吉田純子、石橋隆治、今泉範子、西尾眞友
    • Organizer
      第66回日本薬理学会北部会
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effects of sodium channel blocker amitriptyline on the spontaneous and stimulus-evoked activity of corneal cold-sensitive nerve terminals in intact and tear-deficit guinea-pig eyes.2015

    • Author(s)
      Takayoshi Masuoka, Juana Gallar, Carlos Belmonte
    • Organizer
      The Association for Research in Vision and Ophtalmology
    • Place of Presentation
      Denver, CO, USA
    • Year and Date
      2015-05-02 – 2015-05-07
    • Related Report
      2014 Research-status Report
  • [Presentation] Resveratrol Downregulated Caveolin-1 in A431 Cells2015

    • Author(s)
      Noriko Imaizumi, Junko Yoshida, Takaharu Ishibashi, Takayoshi Masuoka, and Matomo Nishio
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Effects of amitriptyline on the spontaneous and stimulus-evoked activity of corneal cold-sensitive nerve terminals2015

    • Author(s)
      Juana Gallar, Takayoshi Masuoka, Carlos Belmonte
    • Organizer
      Association for Ocular Pharmacology and Therapeutics 2015
    • Place of Presentation
      Charleston, SC, USA
    • Year and Date
      2015-02-26 – 2015-03-01
    • Related Report
      2014 Research-status Report
  • [Book] Muscarinic Receptor: From Structure to Animal Models, Volume 107 of the series Neuromethods2016

    • Author(s)
      Ikunobu Muramatsu, Hatsumi Yoshiki, Kiyonao Sada, Junsuke Uwada, Takanobu Taniguchi, Takayoshi Masuoka, Matomo Nishio
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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