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Common molecular mechanisms regulating murine breast cancer stem cells and leukemia stem cells

Research Project

Project/Area Number 26670135
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionHiroshima University (2015)
Kanazawa University (2014)

Principal Investigator

NAKA Kazuhito  広島大学, 原爆放射線医科学研究所, 准教授 (70372688)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsがん幹細胞 / 乳がん幹細胞 / CML幹細胞 / 代謝産物 / メタボローム / 乳がん / 休眠状態 / MMTV-PyVT / 再発
Outline of Final Research Achievements

Although it is now widely accepted that cancer stem cells are the cell-of-origin of the vast majority of mature cancer cells and are reportedly responsible for the recurrence of disease following anti-cancer therapy, the molecular mechanisms regulating cancer stem cells in epithelial tumors has remained elusive. The biological characteristics of mature cancer cells appear to be distinct among breast cancer cells originate from endoderm and leukemia cells originate from mesoderm. However, I hypothesized that common molecular mechanisms such as stem cell quiescence and/or therapeutic resistance might sustain the long-term survival of breast cancer stem cells and chronic myelogenous leukemia (CML) stem cells. In this study, I used sophisticated metabolomics techniques to investigate the distinct and common molecular mechanisms maintaining self-renewal capacity of murine breast cancer stem cells and murine CML stem cells in vivo.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (20 results)

All 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Invited: 1 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Int'l Joint Research] CHA大学校/カトリック大学校ソウル聖母病院(韓国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] スタンフォード大学/メタボロン社(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Novel oral transforming growth factor-β signaling inhibitor EW-7197 eradicates CML-initiating cells.2016

    • Author(s)
      Naka K, Ishihara K, Jomen Y, Jin CH, Kim DH, Gu YK, Jeong ES, Li S, Krause DS, Kim DW, Bae E, Takihara Y, Hirao A, Oshima H, Oshima M, Ooshima A, Sheen YY, Kim SJ, Kim DK.
    • Journal Title

      Cancer Sci.

      Volume: 107 Issue: 2 Pages: 140-148

    • DOI

      10.1111/cas.12849

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Transcriptome sequencing of hematopoietic stem cells and chronic myelogenous leukemia stem cells.2015

    • Author(s)
      Kim J., Kim S.J., Naka K.
    • Journal Title

      Genomics Data.

      Volume: 7 Pages: 57-59

    • DOI

      10.1016/j.gdata.2015.11.017

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dipeptide species regulate nutrient signalling essential for the maintenance of chronic myelogenous leukaemia stem cells.2015

    • Author(s)
      Naka K, Jomen Y, Ishihara K, Kim J, Ishimoto T, Bae E, Mohney R, Stirdivant SM, Oshima H, Oshima M, Kim DW, Nakauchi H, Takihara Y, Kato Y, Ooshima A, Kim SJ.
    • Journal Title

      Nature Communication

      Volume: 6 Issue: 1 Pages: 8039-8039

    • DOI

      10.1038/ncomms9039

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Homozygous Deletions at 3p22, 5p14, 6q15, and 9p21 Result in Aberrant Expression of Tumor Suppressor Genes in Gastric Cancer.2015

    • Author(s)
      Lee B., Yoon K.Y., Lee S.H., Kang J.M., Kim J.I., Shim S.H., Kim H.-M., Song S.H., Naka K., Kim A.K., Yang H.-K., Kim S.J.
    • Journal Title

      Genes, Chromosomes and Cancer.

      Volume: 54 Issue: 3 Pages: 142-155

    • DOI

      10.1002/gcc.22226

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Dipeptide species regulate nutrient signalling essential for the maintenance of chronic myelogenous leukaemia stem cells (Poster)2016

    • Author(s)
      Kazuhito Naka, Akira Ooshima, Yukio Kato, Yoshihiro Takihara, and Seong-Jin Kim
    • Organizer
      Keystone Symposia, Stem Cells and Cancer
    • Place of Presentation
      コロラド州・ブリッケンリッジ (米国)
    • Year and Date
      2016-03-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] CML幹細胞をターゲットとする新しい治療戦略 (ワークショップ)2015

    • Author(s)
      仲 一仁, 瀧原義宏
    • Organizer
      第38回分子生物学会年会
    • Place of Presentation
      神戸国際会議場,神戸市
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] がん幹細胞の抗がん剤抵抗性メカニズム (指定演題)2015

    • Author(s)
      仲 一仁
    • Organizer
      第18回癌と骨病変研究会
    • Place of Presentation
      千代田放送会館,東京
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] CML幹細胞をターゲットとする新しい治療戦略 (ランチョンセミナー)2015

    • Author(s)
      仲 一仁
    • Organizer
      第77回日本血液学会学術集会
    • Place of Presentation
      ANAクラウンプラザホテル金沢,金沢市
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] TGFβ Signaling Inhibitor eradicates CML Stem Cells2015

    • Author(s)
      Kazuhito Naka, Kaori Ishihara, Yoshie Jomen
    • Organizer
      平成26年度 新学術領域研究 「がん研究分野の特性等を踏まえた支援活動」冬期公開シンポジウム
    • Place of Presentation
      一橋記念講堂(東京都,千代田区)
    • Year and Date
      2015-01-26 – 2015-01-27
    • Related Report
      2014 Research-status Report
  • [Presentation] TGFβ Signaling Inhibitor eradicates CML Stem Cells2015

    • Author(s)
      Kazuhito Naka, Kaori Ishihara, Yoshie Jomen
    • Organizer
      Fourth Joint International Symposium on TGF-β and Cancer
    • Place of Presentation
      つくば国際会議場(茨城県,つくば市)
    • Year and Date
      2015-01-12 – 2015-01-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Novel Therapeutic Strategy for Targeting CML stem cells2014

    • Author(s)
      仲 一仁
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県,横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] The Novel Oral TGFβ Signaling Inhibitor Targets Chronic Myeloid Leukemia Stem Cells2014

    • Author(s)
      Kazuhito Naka, Dong-Hyun Kim, Shaoguang Li, Yhun Yhong Sheen, Akira Oshima, Seong-Jin Kim, and Dae-Kee Kim
    • Organizer
      Sixteenth Annual John Goldman Conference on Chronic Myeloid Leukemia Biology and Therapy
    • Place of Presentation
      Philadelphia, PA, USA
    • Year and Date
      2014-09-08
    • Related Report
      2014 Research-status Report
  • [Book] 血液内科2015

    • Author(s)
      仲 一仁
    • Total Pages
      6
    • Publisher
      CML幹細胞を標的とする治療戦略の可能性
    • Related Report
      2015 Annual Research Report
  • [Book] 日本臨床 (特集がん幹細胞)2015

    • Author(s)
      仲 一仁
    • Total Pages
      6
    • Publisher
      がん幹細胞のTGF-βシグナル伝達
    • Related Report
      2015 Annual Research Report
  • [Book] CML幹細胞を標的とした新しい治療戦略, がん分子標的治療2014

    • Author(s)
      仲 一仁
    • Total Pages
      7
    • Publisher
      メディカルレビュー
    • Related Report
      2014 Research-status Report
  • [Remarks] 金沢大学 がん進展制御研究所 がん幹細胞探索プロジェクト

    • URL

      http://cancerstem55.w3.kanazawa-u.ac.jp/

    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 慢性骨髄性白血病治療剤2015

    • Inventor(s)
      仲 一仁
    • Industrial Property Rights Holder
      広島大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-075195
    • Filing Date
      2015-04-01
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 慢性骨髄性白血病治療剤2015

    • Inventor(s)
      仲 一仁, 定免由枝,石原薫理
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-020709
    • Filing Date
      2015-02-04
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2022-01-27  

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