Analyses of gene regulatory network in VMH underlying female sexual behavior

• Project/Area Number: 26670145
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Kyushu University
• Principal Investigator: Shima Yuichi 九州大学, 医学(系)研究科(研究院), 助教 (80425420)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 視床下部 / 性行動 / 転写 / 核内受容体 / 神経 / ニューロン / トランスジェニックマウス / トランスクリプトーム / クロマチン免疫沈降

Outline of Final Research Achievements

The ventromedial Hypothalamic Nucleus (VMH) is well known as a center for female sexual behavior, and Ad4BP/SF-1 is a transcription factor expressed in VMH. Ad4BP/SF-1 gene disruption in the VMH resulted in disappearance of lordosis, representative female sexual behavior, suggesting that gene regulatory networks regulated by Ad4BP/SF-1 in VMH is essential for female sexual behavior. In this project, we attempted to identify target genes of Ad4BP/SF-1 in VMH, and thereby clarify the molecular machinery underlying female sexual behavior.

Research Products

• [Journal Article] Fetal Leydig Cells are Androgen Independent and Persist as an Androgen-independent Subpopulation in the Postnatal Testis (2015)
  • Author(s): Yuichi Shima, Sawako Matsuzaki, Kanako Miyabayashi, Hiroyuki Otake, Takashi Baba, Shigeaki Kato, Ilpo Huhtaniemi, Ken-ichirou Morohashi
  • Journal Title: Mol Endocrinol Volume: 29 Issue: 11 Pages: 1581-1593
  • DOI: 10.1210/me.2015-1200
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Glycolytic gene as the targets of nuclear receptor Ad4BP/SF-1 (2014)
  • Author(s): Takashi Baba, Hiroyuki Otake, Tetsuya Sato, Kanako Miyabayashi, Yurina Shishido, Chia-Yih Wang, Yuichi Shima, Hiroshi Kimura, Mikako Yagi, Yasuhiro Ishihara, Shinjiro Hino, Hidesato Ogawa, Mitsuyoshi Nakao, Takeshi Yamazaki, Dongchon, Kang, Yasuyuki Ohkawa, Mikita Suyama, Bon-Chu Chung, Ken-ichirou Morohashi
  • Journal Title: Nature Commun Volume: 5 Issue: 1 Pages: 3634-3634
  • DOI: 10.1038/ncomms4634
  • Peer Reviewed / Open Access
• [Journal Article] 出生後の清掃における胎仔型ライディッヒ細胞の細胞運命と生理機能の解明 (2014)
  • Author(s): 嶋雄一、宮林香奈子、松崎佐和子、井上実紀、諸橋憲一郎
  • Journal Title: 日本生殖内分泌学会雑誌 Volume: 19 Pages: 45-50
• [Presentation] 胎仔型ライディッヒ細胞と成獣型ライディッヒ細胞の細胞系譜の解明 (2015)
  • Author(s): 嶋雄一、宮林香奈子、井上実紀、諸橋憲一郎
  • Organizer: 第19回日本生殖内分泌学会学術集会
  • Place of Presentation: 千里ライフサイエンスセンタ
  • Year and Date: 2015-01-10
• [Presentation] 胎仔型ライディッヒ細胞の細胞運命と生理機能の解明 (2014)
  • Author(s): 嶋雄一、宮林香奈子、松崎佐和子、井上実紀、馬場崇、大竹博之、諸橋憲一郎
  • Organizer: 第87回日本内分泌学会学術総会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2014-04-24 – 2014-04-26
• [Remarks] 九州大学大学院 医学研究院 分子生命科学系部門 性差生物学講座
  • URL: http://www.med.kyushu-u.ac.jp/seisaseibutu/