Analyses of gene regulatory network in VMH underlying female sexual behavior
| Project/Area Number |
26670145
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
Shima Yuichi 九州大学, 医学(系)研究科(研究院), 助教 (80425420)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 視床下部 / 性行動 / 転写 / 核内受容体 / 神経 / ニューロン / トランスジェニックマウス / トランスクリプトーム / クロマチン免疫沈降 |
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| Outline of Final Research Achievements |
The ventromedial Hypothalamic Nucleus (VMH) is well known as a center for female sexual behavior, and Ad4BP/SF-1 is a transcription factor expressed in VMH. Ad4BP/SF-1 gene disruption in the VMH resulted in disappearance of lordosis, representative female sexual behavior, suggesting that gene regulatory networks regulated by Ad4BP/SF-1 in VMH is essential for female sexual behavior. In this project, we attempted to identify target genes of Ad4BP/SF-1 in VMH, and thereby clarify the molecular machinery underlying female sexual behavior.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Glycolytic gene as the targets of nuclear receptor Ad4BP/SF-12014
Author(s)
Takashi Baba, Hiroyuki Otake, Tetsuya Sato, Kanako Miyabayashi, Yurina Shishido, Chia-Yih Wang, Yuichi Shima, Hiroshi Kimura, Mikako Yagi, Yasuhiro Ishihara, Shinjiro Hino, Hidesato Ogawa, Mitsuyoshi Nakao, Takeshi Yamazaki, Dongchon, Kang, Yasuyuki Ohkawa, Mikita Suyama, Bon-Chu Chung, Ken-ichirou Morohashi
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Journal Title
Nature Commun
Volume: 5
Issue: 1
Pages: 3634-3634
DOI
Related Report
Peer Reviewed / Open Access
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