| Project/Area Number |
26670149
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kobe University (2015)
Tohoku University (2014) |
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Principal Investigator |
YASUDA Takao 神戸大学, 医学(系)研究科(研究院), 助教 (70598482)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | Slp2-a / ezrin / 腎臓尿細管上皮細胞 / 嚢胞性腎疾患 / 慢性腎不全 / 細胞肥大 |
|---|
| Outline of Final Research Achievements |
Polycystic kidney diseases (PKDs) are the most frequent genetic cause of end-stage renal disease that are characterized by renal cyst growth. Since there is still no treatment for PKDs, determining the molecular mechanisms of the pathogenesis of PKDs is crucial to the search for therapeutic targets. We found the critical involvement of synaptotagmin-like protein 2-a (Slp2-a) and its signaling in the control of renal cell size and morphogenesis by using Madin-Darby canine kidney II (MDCK II) cells and rodent models of human nephronophthisis. Modulation of the activity of Slp2-a signaling would be a novel effective treatment option for PKDs.
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