| Project/Area Number |
26670150
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 転写因子 / がん / がん遺伝子 / 酸化ストレス応答 / ストレス応答 / 合成致死 / スクリーニング / ウイルス / 遺伝子導入 |
|---|
| Outline of Final Research Achievements |
NRF2 is a master transcriptional activator playing a critical role in the defense mechanism against oxidative insults. NRF2 activates genes encoding cytoprotective enzymes and antioxidant proteins in response to electrophiles and reactive oxygen species (ROS), conferring resistance against xenobiotic and oxidative stress. While NRF2 activation is beneficial to our health, NRF2 is responsible for the malignant progression of various human cancers. Inhibition of NRF2 activity is considered to be effective for the regression of tumors, but it also gives disadvantage to cancer-bearing hosts by reducing the anti-cancer immunity and stress response ability. In this study, we have established a screening system for the exploration of synthetic lethal factors with NRF2 in cancer cells.
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