| Project/Area Number |
26670151
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松永 耕一 群馬大学, 生体調節研究所, 助教 (20570162)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | インスリン / 糖尿病 / ケミカルバイオロジー / ベータ細胞 / インスリン分泌 / insulin / β細胞 / ケミカルライブラリ |
|---|
| Outline of Final Research Achievements |
Over 400 million people had diabetes mellitus in the world, and new drug development is important for the reason. We established a high-throughput screening assay system for the identification of chemical compounds that enhance (or inhibit) insulin secretion. In consequence, we identified six effective chemicals. To investigate molecular mechanism of these chemical compound activated (or inhibited) insulin secretion, we performed comprehensive binding assay with these chemicals in INS1 832/13 cells. we identified mitochondrial protein as the one of activator of chemical. Therefore, we obtained basic data to develop a new drug for diabetes.
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