Identification of the specific metabolic system for cellular senescence and tumorigenesis
Project/Area Number |
26670163
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
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Research Institution | Kyushu University (2016) Keio University (2014-2015) |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
Akiko Kubo 慶應義塾大学, 医学部, 特任講師 (50455573)
Takako Hishiki 慶應義塾大学, 医学部, 特任講師 (10338022)
Yuki Sugiura 慶應義塾大学, 医学部, 特任講師 (30590202)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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Keywords | 細胞老化 / 代謝 / 不死化 / 癌化 / 低酸素 / 細胞周期 / メタボロミクス / 老化 |
Outline of Final Research Achievements |
We have performed metabolome analysis on fresh, senescent, and immortalized stage in “cellular senescence to spontaneous immortalization model” using mouse embryonic fibroblasts (MEFs) 3T3 technique. Several senescent stage-specific and immortalization-specific metabolic pathways were determined, and tetracycline-inducible tunable senescence / immortalization cellular model were under development.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Acquired platinum resistance involves epithelial-to-mesenchymal transition through ubiquitin ligase FBXO32 dysregulation2016
Author(s)
Tanaka N, Kosaka T, Miyazaki Y, Mikami S, Niwa N, Otsuka Y, Minamishima YA, Mizuno R, Kikuchi E, Miyajima A, Sabe H, Okada Y, Uhlen P, Suematsu M, Oya M
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Journal Title
JCI insight
Volume: 1
Issue: 18
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Obesity-induced kidney injury is attenuated by amelioration of aberrant PHD2 activation in proximal tubules2016
Author(s)
Futatsugi K, Tokuyama H, Shibata S, Naitoh M, Kanda T, Minakuchi H, Yamaguchi S, Hayashi K, Minamishima YA, Yanagita M, Wakino S, Itoh H
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Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 365331-12
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Inhibition of the Oxygen Sensor PHD2 in the Liver Improves Survival in Lactic Acidosis by Activating the Cori Cycle2015
Author(s)
Suhara T, Hishiki T, Kasahara M, Hayakawa N, Oyaizu T, Nakanishi T, Kubo A, Morisaki H, Kaelin WG Jr., Suematsu M, Minamishima YA§. (§Corresponding author)
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 112
Issue: 37
Pages: 11642-7
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Targeting oxygen sensor PHD for the treatment of metformin-associated lactic acidosis (MALA)2017
Author(s)
Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Minamishima S, Kubo A, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA*
Organizer
Keystone Symposia “Adaptations to Hypoxia in Physiology and Disease (X4)”
Place of Presentation
Whistler Conference Centre , Whistler, BC, Canada
Related Report
Int'l Joint Research
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[Presentation] Targeting the oxygen sensor PHD (prolyl hydroxylase) for the treatment of lethal lactic acidosis2017
Author(s)
Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Minamishima S, Kubo A, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA*
Organizer
第90回日本薬理学会年会
Place of Presentation
長崎ブリックホール/長崎新聞文化ホール
Related Report
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[Presentation] Glycosaminoglycan as an energy source for pancreatic cancer cells.2016
Author(s)
Shotaro Kishimoto*, Yoji Andrew Minamishima*, Noriyo Hayakawa and Makoto Suematsu (*Equally contributed)
Organizer
10th AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Therapeutics.
Place of Presentation
Hyatt Regency Maui (Maui, Hawaii, U.S.A.)
Year and Date
2016-02-18
Related Report
Int'l Joint Research
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[Presentation] Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle2015
Author(s)
Tomohiro Suhara*, Takako Hishiki, Masataka Kasahara, Noriyo Hayakawa, Tomoko Oyaizu, Tsuyoshi Nakanishi, Akiko Kubo, Hiroshi Morisaki, William G. Kaelin Jr., Makoto Suematsu, Yoji Andrew Minamishima
Organizer
第3回低酸素研究会
Place of Presentation
早稲田大学先端生命医科学センター (東京都新宿区)
Year and Date
2015-07-25
Related Report
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[Presentation] Inactivating HIF-prolyl hydroxylase PHD2 in liver improves survival after lactic acidosis by activating Cori cycle2015
Author(s)
Tomohiro Suhara, Takako Hishiki, Masataka Kasahara, Noriyo Hayakawa, Tomoko Oyaizu, Tsuyoshi Nakanishi, Akiko Kubo, Hiroshi Morisaki, Makoto Suematsu, Yoji Andrew Minamishima*
Organizer
Keystone Symposia “Hypoxia: From Basic Mechanisms to Therapeutics (E3)”.
Place of Presentation
Royal Dublin Society (Dublin, Ireland)
Year and Date
2015-05-14
Related Report
Int'l Joint Research
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