| Project/Area Number |
26670163
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kyushu University (2016)
Keio University (2014-2015) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Akiko Kubo 慶應義塾大学, 医学部, 特任講師 (50455573)
Takako Hishiki 慶應義塾大学, 医学部, 特任講師 (10338022)
Yuki Sugiura 慶應義塾大学, 医学部, 特任講師 (30590202)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 細胞老化 / 代謝 / 不死化 / 癌化 / 低酸素 / 細胞周期 / メタボロミクス / 老化 |
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| Outline of Final Research Achievements |
We have performed metabolome analysis on fresh, senescent, and immortalized stage in “cellular senescence to spontaneous immortalization model” using mouse embryonic fibroblasts (MEFs) 3T3 technique.
Several senescent stage-specific and immortalization-specific metabolic pathways were determined, and tetracycline-inducible tunable senescence / immortalization cellular model were under development.
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