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Molecular mechanism of DDAH2 associated stromal formation in lung adenocarcinoma

Research Project

Project/Area Number 26670172
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionUniversity of Tsukuba

Principal Investigator

Noguchi Masayuki  筑波大学, 医学医療系, 教授 (00198582)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsDDAH2 / lung adenocarcinoma / malignant stroma / angiogenesis
Outline of Final Research Achievements

We examined the functional significance of DDAN2 expression in the stroma of the lung adenocarcinoma. Using immunohistochemistry, we examined expression of DDAH2. Interestingly, almost all cases of MIA and invasive adenocarcinoma were positive for DDAH2, while only half of pre-invasive lesions were positive. High expression of DDAH2 was significantly associated with poor outcome (p<0.026). Expression of both DDAH2 and eNOS by western blotting showed both to be expressed at a significantly higher level in invasive adenocarcinoma than in AIS and normal lung. DDAH2 is expressed in carcinoma-associated fibroblast and might play an important role in tumor invasion by promoting tumor angiogenesiss through an increase of NO production.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (7 results) (of which Int'l Joint Research: 3 results,  Invited: 6 results) Book (2 results)

  • [Journal Article] Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma.2016

    • Author(s)
      Shiozawa T,Iyama S,Toshima S,Sakata A,Usui S,Minami Y,Sato Y,Hizawa N,Noguchi M.
    • Journal Title

      Virchows Archiv

      Volume: 468(2) Issue: 2 Pages: 179-190

    • DOI

      10.1007/s00428-015-1863-z

    • NAID

      120007135606

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunocytochemical staining for stratifin and OCIAD2 in bronchial washing specimens increases sensitivity for diagnosis of lung cancer.2014

    • Author(s)
      Itoguchi N1, Nakagawa T, Murata Y, Li D, Shiba-Ishii A, Minami Y, Noguchi M.
    • Journal Title

      Cytopathology.

      Volume: - Issue: 6 Pages: 354-361

    • DOI

      10.1111/cyt.12220

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ECT2 amplification and overexpression as a new prognostic biomarker for early-stage lung adenocarcinoma2014

    • Author(s)
      Yoshihiko Murata, Yuko Minami, Reika Iwakawa, Jun Yokota, Shingo Usui, Koji Tsuta, Kouya Shiraishi, Shingo Sakashita, Kaishi Satomi, Tatsuo Iijima and Masayuki Noguchi
    • Journal Title

      Cancer Science

      Volume: 105 Issue: 4 Pages: 490-497

    • DOI

      10.1111/cas.12363

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 新WHO分類における肺癌分類の要点と問題点2015

    • Author(s)
      野口 雅之
    • Organizer
      第56回日本肺癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2015-11-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Lung Carcinogenesis「Molecular Pathology of Alveolar Premalignancy」2015

    • Author(s)
      野口 雅之
    • Organizer
      IASLC2015(the 16th IASLC World Conference on Lung Cancer)
    • Place of Presentation
      Colorado Convention Center(Colorado,United States of America)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The New WHO Classification of Lung Adenocarcinoma, points for diagnosis and biological significance2015

    • Author(s)
      野口 雅之
    • Organizer
      APIAP 2015: The 9th Asia Pacific IAP Congress
    • Place of Presentation
      Brisbane Convention & Exhibition Centre(Brisbane , Australia)
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Adenocarcinoma of the lung2015

    • Author(s)
      野口 雅之
    • Organizer
      Pathology Expert Forum: The WHO Classification of Lung Tumors2015
    • Place of Presentation
      GIS NTU Convention Center(Taipei、Taiwan)
    • Year and Date
      2015-05-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 「宿題報告2」肺腺癌の組織発生と悪性化の病理学2015

    • Author(s)
      野口 雅之
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 特別講演「Early genetic and phenotypic alterations of lung adenocarcinoma」2014

    • Author(s)
      野口 雅之
    • Organizer
      Training of the Education Program for Pathology and Genetic Tests
    • Place of Presentation
      つくば臨床検査教育・研究センター
    • Year and Date
      2014-11-10 – 2014-11-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Scientific program :Pulmonary pathology sessions2014

    • Author(s)
      野口 雅之
    • Organizer
      The 30th Congress of the International Academy of Pathology(IAP2014)
    • Place of Presentation
      Bangkok Convention Centre at CentralWorld Bangkok,Thailand
    • Year and Date
      2014-10-05 – 2014-10-11
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] WHO Classification of Tumours ,Vol.72015

    • Author(s)
      W.D.Travis,E.Brambilla, A.P.Burke,A.Marx,A.G.Nicholson,Noguchi M.
    • Total Pages
      412
    • Publisher
      WORLD HEALTH ORGANIZATION:Lyon,France
    • Related Report
      2015 Annual Research Report
  • [Book] CLASSIC  ANATOMIC PATHOLOGY AND LUNG CANCER.2014

    • Author(s)
      Ignacio I,Wistuba,Elisabeth Brambilla,M Noguchi.
    • Total Pages
      24
    • Publisher
      The IASLC Multidisciplinary Approach to Thoracic Oncology.
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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